abstract β-thalassemia major (β –tm) is the most common thalassemia severe phenotype among iranians. in recent years, molecular understanding of pathogenesis of β –tm has provided a great opportunity regarding diagnostic issues. creating comprehensive molecular databases provides highly sensitive diagnostic tools for β –tm and effective prenatal diagnosis (pnd) molecular screening tests. despit...

background and aims. the role of cytokines in the immunopathogenesis of oral lichen planus (olp) has received much attention. the aim of this study was to evaluate the serum levels of tnf-α and tgf-β in patients with olp in an iranian population. materials and methods. thirty-two patients with olp and 32 age-matched healthy volunteers as a control group were included in this study. serum tests ...

conclusions the β-lactamase disk test is appropriately sensitive to detect esbls in mdr isolates of e. coli. background most urinary tract infections (utis) are caused by escherichia coli (e. coli) species. due to infections outbreaks of e. coli strains with multiple mechanisms of resistance to β-lactam antibiotics, the sensitivity of confirmatory tests to detect the extended spectrum β-lactama...

background and objectives: pseudomonas aeruginosa is a frequent opportunistic pathogen in health care associated infections that is highly resistant to the majority of β-lactams. the aims of this study were to access the antimicrobial susceptibility pattern of p. aeruginosa isolated from educational hospitals of qazvin and alborz provinces, to determine the prevalence of metallo-β-lactamase (mb...

background escherichia coli (e. coli) species are able to produce extended-spectrum β-lactamases (esbls) that cause high resistance to the beta-lactam antibiotics. therefore, determining the antibiotic susceptibility patterns in resistant organisms is necessary for suitable therapeutic approaches. patients and methods totally, 260 clinical isolates of e. coli were collected from hospitals in te...

background: in order to select a better antibiotic choice for treatment of pseudomonas aeruginosa infections, this study was conducted to determine the frequency of resistance to some antipseudomonal β-lactams in p. aeruginosa isolates from patients in tehran, iran. in addition, the relation between presence of genes known to be responsible for resistance to β-lactams (ampc, mexc1,2,and mexc3,4...

background: resistant strains of pseudomonas aeruginosa to imipenem was medical treatment problem, especiallyin burnt units of hospitals. objectives: this study was conducted to evaluate the antimicrobial effect of fe2o3 nanoparticles alone and functionalized with imipenem on p. aeruginosa starins producing metallo b-lactamases (mbl).materials and methods: a disk diffusion method was used to is...

background transfusion-induced iron overload leads to many complications in patients with β-thalassemia major. this study aimed to compare the level of iron stored in the liver and heart measured by mri t2 * with ferritin levels in these patients. materials and methods this study was done on 52 patients with β-thalassemia major aged 7 to 29 years. serum ferritin level was checked and heart and ...