C-reactive protein (CRP) and serum amyloid P component (SAP), two major classical pentraxins in humans, are soluble pattern recognition molecules that regulate the innate immune system, but their chaperone activities remain poorly understood. Here, we examined their effects on the amyloid fibril formation from Alzheimer's amyloid β (Aβ) (1-40) and on that from D76N β2-microglobulin (β2-m) which...

BACKGROUND/AIMS β2-microglobulin (β2-MG) is freely filtered at the glomerulus and subsequently reabsorbed and catabolized by proximal renal tubular cells. Urinary β2-MG is an early and sensitive biomarker of acute kidney injury; however, its utility as a biomarker of immunoglobulin A nephropathy (IgAN) is unclear. METHODS We included urinary β2-MG levels in the routine laboratory examination ...

Diabetic nephropathy (DN) is a main cause of end-stage renal disease. Early diagnosis and intervention can greatly increase the prognosis. This study was aimed at investigating the clinical significance of urinary excretion of proteins with low weight including microalbuminuria (MA), α1-microprotein (A1M), β2-microglobulin (β2-MG) and retinol binding protein (RBP) as indicators for early diagno...

β2-microglobulin (β2-m) has become the focus of intense scrutiny since the discovery of its undesirable roles promoting osteomimicry and cancer progression. β2-m is a well-known housekeeping protein that forms complexes with the heavy chain of major histocompatibility complex class I molecules, which are heterodimeric cell surface proteins that present antigenic peptides to cytotoxic T cells. O...

Objective This study aimed to investigate the correlations of long non-coding RNA ANRIL (lncRNA ANRIL), microRNA (miR)-34a, miR-125a and miR-186 with disease risk, clinical features prognosis multiple myeloma (MM).Method Totally, 87 MM patients 30 controls were recruited. LncRNA its target miRNAs (miR-34a, miR-186) in bone marrow derived plasma cells detected by RT-qPCR. Treatment response was ...

Hematopoietic stem cell transplantation is a life-saving therapy in patients suffering from acute leukemia. However, kidney complications developed after performing hematopoietic can affect the course and prognosis of disease with This study aimed at assessing functional status kidneys leukemia who have undergone transplantation. The has observed group lymphoblastic myeloid It been discovered t...

GFR markers Among newer GFR markers in ARF, serum cystatin C deserves evaluation since it has been shown more sensitive and accurate than serum creatinine in several settings, but has not been validated as a GFR indicator in ARF (1-2). Another endogenous marker, β2-microglobulin, has been suggested as a GFR estimate (3). Measuring tubular enzymuria could facilitate the early detection of renal ...