نتایج جستجو برای: κb
تعداد نتایج: 29121 فیلتر نتایج به سال:
Background and objectives: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inhibition results in an increase in apoptosis. It has been demonstrated that NF-κB subunit p65 phosphorylation at the IκB kinase phosphorylation site serine 536 (Ser536) is essential for the NF-κB nuclear translocation and activation. Therefore, NF-κB can be downregulated by suppressing its phosph...
التهاب یکی از واکنشهای دفاعی بدن در برابر میکروارگانیسمها و عوامل حساسیتزا است. مسیر NF-Κb (Nuclear factor kappa-light-chain-enhancer of activated B cells) یک جزء ضروری از پاسخهای التهابی دخیل در تعدادی از بیماریهای دستگاه تنفسی مانند آسم و بیماری انسداد مزمن ریوی (COPD) است. در طب سنتی، گیاه Eucalyptus globulus Labill. از تیره Myrtaceae به شکل استنشاقی برای بیماریهای عفونی و التهابی دستگ...
Objectives: Epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells (RTECs) is a pathogenic factor for interstitial fibrosis (RIF). Interleukin-33 (IL-33) related to the occurrence and development RIF, but underlying mechanism remains unclear. Here, we investigated whether IL-33 mediates EMT RTECs by activating NF-κB/Twist1 signalling pathway. Methods: In vivo, RIF animal mode...
the inhibition of the inducible nitric oxide synthase (inos), cyclooxygenase 2 (cox-2) and nuclear factor-κb (nf-κb) production are research targets of attract in the field of anti-inflammatory drug development. therefore, this study was designed to investigate the anti-inflammatory effects of novel thiazolidinone derivatives using a cellular model of lipopolysaccharide (lps)-stimulated murine ...
مقدمه: سرطان خون از جمله عوامل عمده مرگ و میر بشمار می رود که به دلیل بروز مقاومت دارویی، داروهای شیمی درمانی روز توانایی پاسخ به آن را ندارند. بنابراین همیشه دارویی جدید جهت درمان نیاز است. ترکیبات مهار کننده آنزیم سیکلوکسیژناز-2 می توانند کمک کننده باشند و همراه با داروهای متداول شیمی درمانی باعث کاهش دوز مصرفی آنها گردند. در این مطالعه اثرات سمیت سلولی و تغییرات مورفولوژیک ترکیبات a (3-(4-ch...
Background: Inflammation plays a critical role in the promotion of hepatocyte damage and liver fibrosis. In recent years the protective role of exercise and royal jelly (RJ), has been suggested for metabolic and inflammatory disorders. In this study, we aimed to evaluate the effects of aerobic training (AT) and RJ on pro-inflammatory markers in a rat's model of a high-fat diet (HFD). Methods: ...
Abstract Objectives The aim of this study is to investigate the effects radiofrequency radiation (RFR) on apoptosis, proliferation, stress response, and inflammation markers in colorectal cancer cells. Methods We tested intermittent exposure RFR at different frequencies two cell lines; HCT-116 DLD-1. Protein levels were subsequently analyzed by ELISA. Results led a decrease P53, p-P53, p-P38, p...
Nuclear factor-κB (NF-κB) is important in inflammatory skin diseases, including contact dermatitis (Th1 inflammation), atopic (Th2 and psoriasis (Th17 inflammation). In fact, molecularly targeted drugs against tumor necrosis factor (TNF), which both upstream downstream of NF-κB have been demonstrated to be effective diseases such as psoriasis. The linear ubiquitination by ubiquitin chain assemb...
objective(s): the objective of this study was to investigate the hepatoprotective effect of licochalcone b (lcb) in a mice model of carbon tetrachloride (ccl4)-induced liver toxicity. materials and methods: hepatotoxicity was induced in mice by a single subcutaneous injection (sc) of ccl4. the lcb was administered orally once a day for seven days (po) as pretreatment at three doses of 1, 5, and...
Abstract Background Necrotizing enterocolitis (NEC) remains a fatal gastrointestinal disorder in neonates and has very limited therapeutic options. Sialylated human milk oligosaccharides (SHMOs) improve pathological changes experimental NEC models. The objectives of this study were to investigate the involvement NLRP3 inflammasome pathology explore effects SHMOs on toll-like receptor 4 (TLR4)/n...
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