BACKGROUND Accumulating evidence implicates the transcription factor NF-κB as a positive mediator of tumor metastasis, but the molecular mechanism(s) involved in this process remains largely unknown. In this study, we investigated the role of NF-κB signaling pathway in the regulation of CXC chemokine receptor-4 (CXCR4) in neuroblastoma metastasis. MATERIAL AND METHODS NF-κB, CXCR4 mRNA and pr...

Chemotherapy with 5-fluorouracil (5-FU) is commonly used in combination therapy for esophageal squamous cell carcinoma (ESCC), but its efficacy is limited in certain patients. Recent studies suggest that constitutive activation of nuclear factor-κB (NF-κB) has a critical role in tumorigenesis and is associated with poor prognosis and resistance to chemoradiation therapy in many types of human c...

Nuclear factor (NF)-κB transcription factors are pivotal regulators of innate and adaptive immune responses, and perturbations of NF-κB signaling contribute to the pathogenesis of immunological disorders. NF-κB is a well-known proinflammatory mediator, and its deregulated activation is associated with the chronic inflammation of autoimmune diseases. Paradoxically, NF-κB plays a crucial role in ...

BACKGROUND Nuclear factor κB (NF-κB)-mediated pathways have been widely implicated in cell survival, development and tumor progression. Although the molecular events of determining NF-κB translocation from cytoplasm to nucleus have been extensively documented, the regulatory mechanisms of NF-κB activity inside the nucleus are still poorly understood. Being a special member of macro domain prote...

conclusions il-33 may be a potential new agent to attenuate rir injury by reducing inflammatory cell infiltration and preventing apoptosis. results our data revealed that il-33 pretreatment maintained a better retinal structure, inhibited leukocyte infiltration (il-33 vs. mg with p < 0.01 and il-33 vs. pbs group with p < 0.01), and reduced the apoptosis of retinal ganglion cells (il-33 vs. mg w...

BackgroundCD200-CD200R plays a critical role in regulating the human tumor microenvironment, but its cervical cancer remains unclear.MethodsA total of 62 paraffin blocks tissues were collected from patients. Expression CD200 and cathepsin K (CTSK) para-cancerous was analyzed by immunohistochemistry. Stably transfected cells established HeLa SiHa cells. Human THP-1 monocytes induced to different...

The current paradigm of noncanonical NF-κB signaling suggests that the loss of TRAF2, TRAF3 or cIAP1 and cIAP2 leads to stabilization of NF-κB-inducing kinase (NIK) to activate the noncanonical pathway. Although a crucial role of RIP1 in the TNFα-induced canonical NF-κB pathway has been well established, its involvement in noncanonical activation of NF-κB through the TNFR1 receptor, is unknown....

The NF-κB (nuclear factor κB) family of transcription factors are involved in a myriad of activities, including the regulation of immune responses, maturation of immune cells, development of secondary lymphoid organs and osteoclastogenesis. Fine tuning by positive and negative regulators keeps the NF-κB signalling pathway in check. Microbial products and genetic alterations in NF-κB and other s...

Toll‑like receptor (TLR) 2/4 serves an important regulatory role in nerve tissue injury. However, the downstream and potential mechanisms remain to be elucidated. The present study was designed investigate roles of TLR2/4‑major myeloid differentiation response gene 88 (MyD88)‑NF‑κB signaling pathway development intracranial aneurysm. expression TLR2, TLR4 MyD88 blood normal controls patients wi...

Abstract: Sulforaphane (SPN) is reported to activate the Nrf2/Keap1 complex responsible for protein and gene expression promotion of various antioxidant enzymes. The present study examined role Nrf2 in modulating other signaling pathways involved SPN’s attenuation acrolein (ACL)-induced cardiomyopathy rats. Forty-two rat was categorized into seven 4-week treatment groups: control, SPN, losartan...