Introduction . Macrophages occupy a special place in the formation and coordination of immune response, their population is characterized by heterogeneity, however, two main types are distinguished among them: pro-inflammatory (classically activated) macrophages M1, which activated interferon-γ (IFN-γ) or lipopolysaccharide (LPS) bacteria, produce cytokines, nitric oxide (NO) initiate an anti-i...

We have previously reported the generation of Rassf6 knockout mice using CRISPR/Cas technology. Furthermore, we that RASSF6 is implicated in regulation canonical nuclear factor (NF)-κB signaling pathway and 7,12-dimethylbenz(a)anthracene induced skin inflammation more remarkably than wild-type mice. In this study, investigated role tumorigenesis a two-stage carcinogenesis model initially develo...

experimental evidence suggested that sodium ferulate (sf) and oxymatrine (omt) combination had synergistic anti-inflammatory and antioxidant effects. we hypothesized that sf and omt combination treatment might have protective effects on paraquat-induced acute lung injury. in our study, the swiss mice were randomly divided into seven groups, including control, paraquat (pq), sf (6.2 mg/kg/day); ...

Objective: The development of the human placenta depends on proliferation and differentiation trophoblastic cells. Deficiencies in functions are known to have a critical role progression placental pathologies such as preeclampsia. Therefore, this research, it was aimed evaluate responses cells tumor necrosis factor-α (TNF-α) mediated cellular stress. Materials Methods: In study, stress model se...

The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, and apoptosis. In our search for NF-κB inhibitors from natural resources, we identified yangonin from Piper methysticum as an inhibitor of NF-κB activation. In the present study, we demonstrate that yangonin potently inhibits NF-κB activation through suppression of the tran...

BACKGROUND Previous studies have implicated NF-κB signaling in both cutaneous development and oncogenesis. However, these studies have been limited in part by the lethality that results from extreme over- or under-expression of NF-κB in available mouse models. Even cre-driven tissue specific expression of transgenes, or targeted deletion of NF-κB can cause cell death. Therefore, the present stu...

Objective(s): Aberrant expression of CCL5 has been found in several kinds of inflammatory diseases, and the roles of CCL5 in these diseases have also been reported. However, the role of CCL5 in infantile pneumonia is still unclear. Thus, the function and acting mechanism of CCL5 in the in vitro model of infantile pneumonia were researched in this study. Materials and Methods: Human fetal lung f...

Objective(s): Protosappanin A (PrA) is an effective and major ingredient of Caesalpinia sappan L. The current study was aimed to explore the effect of PrA on atherosclerosis (AS). Materials and Methods: Firstly, the experimental model of AS was established in rabbits by two-month feeding of high fat diet. Then, the rabbits were randomly divided into five groups and treated with continuous high ...

Background: The death of neurons and cerebral edema are the main consequences of stroke. However, inflammatory processes play a key role in aggravating cerebral damage following stroke. The aim of this study was to investigate the effects of Viola odorant extract (VOE) on infarct volume (IV), neurologic deficits (ND), and expression of NF-κB and VCAM-1 in the MCAO model. Method: The animals we...

Both the canonical and noncanonical nuclear factor κB (NF-κB) pathways have been linked to tumorigenesis. However, it remains unknown whether and how the 2 signaling pathways cooperate during tumorigenesis. We report that inhibition of the noncanonical NF-κB pathway significantly delays tumorigenesis mediated by the viral oncoprotein Tax. One function of noncanonical NF-κB activation was to rep...