The present study delineates the cellular responses of dorsal pallium to targeted genetic ablation of the principal preplate neurons of the neocortex. Ganciclovir treatment during prenatal development (E11-E13; where E is embryonic day) of mice selectively killed cells with shared S-phase vulnerability and targeted expression of a GPT [golli promoter transgene, linked to HSV-TK (herpes simplex ...

M e t h o d s Design: Randomized controlled trial (Standard and New Antiepileptic Drugs [SANAD] trial, Arm A) Allocation: Concealed.* Blinding: Unblinded.* Follow-up period: Up to 6 years. Setting: Hospital-based outpatient clinics in the United Kingdom. Patients: 1721 patients (mean age 38 y, 55% men) who had ≥ 2 clinically definite, unprovoked epileptic seizures in the past year and were reco...

Field testing of a proprietary stormwater treatment device (GPT) was undertaken over a one year period at a commercial site located in Sippy Downs, Queensland. The focus of the study was primarily on evaluating the effectiveness of the GPT device in removing pollution in the form of nutrients (Total Suspended Solids, Total Nitrogen, Total Phosphorus) from stormwater runoff. Water quality analys...

General purpose technologies (GPTs) are drastic innovations, such as electrification, the transistor, and the Internet, that are characterized by the pervasiveness in use, innovational complementarities, and technological dynamism. The transitional and long-run dynamic effects of a GPT are analyzed within a quality-ladders model of scale-invariant Schumpeterian growth. The diffusion path of a G...

Adenovirus E1A gene products are capable of modulating the expression of a variety of integrated genes. To study the mechanisms by which this regulation occurs, recombinant retroviruses have been utilized to establish cell lines containing an integrated copy of either the adenovirus E2 or E3 promoter adjacent to the bacterial guanine phosphoribosyl transferase (GPT) gene. These cell lines have ...