Bioengineered organs raised in vitro are candidate substitutes for natural organs in biological, pharmacological and clinical applications. We have studied cell kinetics in a human skin equivalent (HSE) using a combined immunohistochemical and flow cytometric approach. Morphological analysis has shown that, relative to unstimulated natural skin, cell proliferation mainly occurs in the basal lay...

Self-efficacy is a key construct underlying healthy functioning and emotional well-being. Perceptions of uncontrollability, unpredictability, and low self-efficacy are consistently associated with negative mental health outcomes, such as post-traumatic stress disorder (PTSD). To test the causal relation between perceived coping self-efficacy and stress responses we employed a trauma film paradi...

Abstract We assessed preparedness of HSE East elderly long-term care facilities for an influenza outbreak, and identified Public Health Department support needs. We surveyed 166 facilities based on the HSE checklist document for influenza outbreaks, with 58% response rate. Client flu vaccination rates were > 75%; leading barriers were client anxiety and consent issues. Target flu vaccine uptake...

In most children and adults, primary infection with herpes simplex virus 1 (HSV-1) is asymptomatic. However, very rarely (incidence of 1 in 1,000,000), it can cause herpes simplex encephalitis (HSE). HSE also occurs in infants but with a much starker incidence of one in three. This age difference in susceptibility to HSV-1-caused HSE is not well understood. In a recent article in mBio, authors ...

GC-MS analysis identified forty seven and fourteen components in oils extracted using HD and in the volatile fractions extracted using HSE, respectively. eudesm-7(11) en-4-ol (28.46%), α-terpinyl acetate (12%), germacrene D-4-ol(7.3%), 1,8-cineole (6.22%), δ-cadinene (6.49%), bicyclogermacrene (5.20%) and α-cadinol (5.06%) were recorded as the main components of the essential oil and The major ...

The aim of this study was to investigate the amount of binaural squelch effect (BSE) and head shadow effect (HSE) in children who use unilateral cochlear implants (CI) and contralateral hearing aids (HA). The study group consisted of 19 CI recipient children who consistently wore a contralateral HA. Speech sounds were used to evaluate speech perception performance in noise. Testing was performe...

Oligomerization of the heat shock factor (HSF) and its interaction with the heat shock element (HSE) are the hallmark of active transcriptional response to tangible physical or chemical stress. It is unknown if these interactions are subject to control and modulation by developmental cues and thus have tissue or stage specificity. By using promoter sequences containing a canonical HSE from the ...

In Autumn 2004, HSE will launch a quarterly on-line newsletter ‘Science and Research Outlook,’ providing information on the breadth of HSE’s science and engineering activities. Science and Research Outlook will replace the existing HSE quarterly science newsletters, Mainstream Research News and Offshore Research Focus. Users of the newsletter’s interactive website will be able to search and pri...

Heme oxygenase-l is an essential enzyme in heme catabolism, and its human gene promoter contains a putative heat shock element (HHO-HSE). This study was designed to analyze the regulation of human heme oxygenase-l gene expression under thermal stress. The amounts of heme oxygenase-l protein were not increased by heat shock (incubation at 42°C) in human alveolar macrophages and in a human eryth...

Deformable template representations of observed imagery, model the variability of target pose via the actions of the matrix Lie groups on rigid templates. In this paper, we study the construction of minimum mean squared error estimators on the special orthogonal group, SO(n), for pose estimation. Due to the nonflat geometry of SO(n), the standard Bayesian formulation, of optimal estimators and ...