مقدمه  اسکلرودرمی موضعی، جزئی از طیف بیماری­های اسکلروتیک است که به طور اولیه پوست را تحت تاثیر قرار می­دهد و شایع­­ترین آن­ها مورفه آ می­باشد. تا به حال علل و پاتوژنز مورفه آ به طور کامل شناخته نشده است اما فرض بر این است که یک فرایند چند عاملی باعث شروع آبشار التهابی و فیبروتیک می­شود. عوامل محیطی احتمالی دخیل شامل بیماری لایم، تروما، پرتوتابی، داروها و عفونت­های ویروسی است که از میان عوامل ...

Scleroderma is a connective tissue disorder identified with skin thickening and fibrosis together with inflammatory, vascular, and internal organ changes. The prevalence of this condition is three times higher in women than in men. Pregnancy was known to threaten maternal and fetal health in patients with scleroderma. Today, however, the patients have the chance of a successful pregnancy throug...

          POEMS syndrome is a plasmocytic dyscrasia that consists a constellation    of polyneuropathy(p), organomegaly(o), endocrinopathy(e), monoclonal    gammapathy(m) and skin disorders(s).           Herein, we report a case of POEMS syndrome that was referred to  &nbsp...

  Saadati N [1] , MD, Taghavi M [2] , MD    Received: 31 Oct, 2007 Accepted: 12 March, 2008 Abstract  Background and Aims: Scleroderma is a connective tissue disorder characterized by thickening and fibrosis of the skin. Many researchers have postulated in the past that scleroderma may be a risk factor for osteoporosis because this disease not only by a chronic inflammatory state, but also by m...

 ABSTRACT Systemic sclerosis is a disease with skin tightness. Besides of skin involvement, there may be involvement of different organs. Systemic sclerosis may be diffuse or limited, but in both of them Raynoud’s phenomen is common. This phenomen is due to vasoconstriction and vascular insufficiency and is a phenomen that makes problem for the patient and does not have any efficient treatment....

Background: Systemic scleroderma (SSc) is a generalized connective tissue disorder of unknown origin which most notably is characterized by skin thickening and organ damage. Endothelin-1 (ET-1) antibody plays a role in skin fibrosis. The aim of this study was to determine the prevalence and correlation of different manifestations of SSc with ET-1 plasma levels.Methods: This cross-sectiona...

Background & Aims: Scleroderma is a systemic condition with various manifestations in different organs. Among these organs, the lungs are affected very frequently, and the involvement is progressive and significant. Various medications have been suggested and tested in patients with scleroderma and lung involvement, but their efficacy and safety profile differ and enforce a difficult final...

Introduction & Objective: Interstitial lung disease is the leading cause of mortality and morbidity in patients with scleroderma. For this reason an early diagnosis of lung involvement is warranted. The best approach to detect pulmonary disease particularly alveolitis (inflammatory NSIP) as a reversible phase is controversial. The aim of this study is estimating the advantage of HRCT as a non...

Scleroderma- one of the important autoimmune diseases- leads to death of endothelial cells as one of the early events of this disease. The lack of repair after the loss of endothelial cells is observed in these patients and although, its cause has remained unknown. The development of effective treatments for many rheumatoid diseases requires a better understanding of the pathophysiological mech...

Background: Scleroderma is an important chronic disease with unknown ethiology and two subtypes: limited type: Skin involvement limited to distal of extremity and face. Diffuse type: Skin involvement is both distal and proximal of extremity, face and thrunk. Thyroid dysfunction is a main problem in these patients but there is no published data of Iranian scleroderma patients Methods: This is a...