The in vitro metabolism of buprenorphine was investigated to explore new metabolic pathways and identify the cytochromes P450 (P450s) responsible for the formation of these metabolites. The resulting metabolites were identified by liquid chromatography-electrospray ionization-tandem mass spectrometry. In addition to norbuprenorphine, two hydroxylated buprenorphine (M1 and M2) and three hydroxyl...

We demonstrate that, in an appropriate limit, the off-shell M5-brane worldvolume action effectively captures the scalar potential of Seiberg-Witten theory perturbed by a small super-potential and, consequently, any nonsupersymmetric vacua that it describes. This happens in a similar manner to the emergence from M5's of the scalar potential describing certain type IIB flux configurations [1]. We...

We investigated the subtype of presynaptic muscarinic receptors associated with inhibition of acetylcholine (ACh) release in the mouse small intestine. We measured endogenous ACh released from longitudinal muscle with myenteric plexus (LMMP) preparations obtained from M1-M5 receptor knockout (KO) mice. Electrical field stimulation (EFS) increased ACh release in all LMMP preparations obtained fr...

Recently, noncommutative theories have received renewed interest, after it was found that noncommutative theories can be naturally realized in M theory compactified in the presence of constant three-form field background @1# and within string theories as the worldvolume theory of a D-brane with a nonzero constant Neveu-Schwarz ~NS! B field @2,3#. In the case of a D-brane with a constant magneti...

Motivated by Sen's spacetime prescription for the construction of theories with self-dual field strengths, we present a rigid superspace Lagrangian describing noninteracting tensor multiplets living on stack M5-branes and containing all physical constraints fields, yielding on-shell matching degrees freedom. The geometric approach adopted here offers natural realization superdiffeomorphisms is ...