Results of thrombolysis by monotherapy with either tPA or proUK have not lived up to expectations. Since these natural activators are inherently complementary, this property can be utilized to a synergistic advantage; and yet, this has undergone little evaluation. ProUK is no longer available because at pharmacological concentrations it converts to UK in plasma. Therefore, a single site proUK m...

Dissection of the small perforating vessels through the muscle/septum can be difficult, and microsurgical success is closely linked on a clear and well-magnified field vision. Since 2004, Varioscope M5 has been employed in our Plastic Surgery Departments. It is the first and only head-mounted microscope. In this study was examined 10 patients underwent to reconstructive procedures by harvest of...

We have cloned new 5-Hydroxytryptamine 4 (5-HT4) receptor splice variants from mouse (m5-HT4(e)R and m5-HT4(f)R), rat (r5-HT4(e)R), and human brain tissue (h5-HT4(e)R) which differ, as do the previously described 5-HT4 receptor variants, in the length and composition of their intracellular C termini after the common splicing site (L358). These new variants have a unique C-terminal sequence made...

In this note we study the puzzle posed by two M5-branes intersecting on a string (or equivalently, a single M5-brane wrapping a holomorphic four-cycle in C). It has been known for a while that this system is different from all other configurations built using self-intersecting M-branes; in particular the corresponding supergravity solution exhibits various curious features which have remained u...

We consider the low-energy limit of the two-dimensional theory on k M2-branes suspended between a straight M5-brane and a curved M5-brane. We argue that it is described by an N=(2, 2) supersymmetric gauge theory with no matter fields but with a non-trivial twisted superpotential, and also by an N=(2, 2) supersymmetric Landau-Ginzburg model, such that the (twisted) superpotentials are determined...

For the most general supersymmetric solutions of type IIB supergravity consisting of a warped product of AdS5 with a five-dimensional manifold M5, we construct an explicit consistent Kaluza-Klein reduction on M5 to minimal D = 5 gauged supergravity. Thus, any solution of the gauged supergravity can be uplifted on M5 to obtain an exact solution of type IIB supergravity. We also show that for gen...

We study the near-flat space limit for strings on AdS5 × M5, where the internal manifold M5 is equipped with a generic metric with U(1)3 isometry. In the bosonic sector, the limiting sigma model is similar to the one found for AdS5 × S5, as the global symmetries are reduced in the most general case. When M5 is a SasakiEinstein space like T 1,1, Y p,q and Lp,q,r, whose dual CFT’s have N = 1 supe...

The interaction of a high-molecular-weight salivary glycoprotein (agglutinin) with Streptococcus sanguis M5 leads to the formation of bacterial aggregates. We have previously shown that the SSP-5 surface antigen from S. sanguis M5 binds the salivary agglutinin and therefore may be involved in the aggregation process. Here we report the transformation of a nonaggregating Enterococcus faecalis st...

We examine heterotic M-theory with a parallel M5 brane. After deriving the four-dimensional low-energy supergravity potential including open membrane instantons, gaugino condensation and M5 brane instantons, we focus on the first two non-perturbative effects. We find in the pure open membrane case, where the parallel M5 gets stabilized at the middle of the orbifold interval, that the vacuum ene...

The methylation-dependent restriction endonuclease (REase) BisI (G(m5)C ↓ NGC) is found in Bacillus subtilis T30. We expressed and purified the BisI endonuclease and 34 BisI homologs identified in bacterial genomes. 23 of these BisI homologs are active based on digestion of (m5)C-modified substrates. Two major specificities were found among these BisI family enzymes: Group I enzymes cut GCNGC c...