A well known industry application that allows controllable processing times is the manufacturing operations on CNC machines. For each turning operation as an example, there is a nonlinear relationship between the manufacturing cost and its required processing time on a CNC turning machine. If we consider total manufacturing cost (F1) and total weighted completion time (F2) objectives simultaneo...

Gene therapy can be combined with tissue engineering constructs to produce gene-activated matrices (GAMs) with enhanced capacity for repair. Polyethyleneimine (PEI), a non-viral vector, has previously been optimised for high efficiency gene transfer in rat mesenchymal stem cells (rMSCs). The use of PEI to transfect human MSCs (hMSCs) with ephrinB2 is assessed here. Recently a role for the ephri...

Investigation of ion temperature gradient turbulence in gyrokinetic models shows that some of the key features of reduced models associated with saturation by nonlinearly excited damped eigenmodes carry over to gyrokinetics. For nonzonal wavenumbers the frequency spectrum in gyrokinetics is broader by a factor of 10 than simple nonlinear broadening of the most unstable eigenmode. The width, inc...

Bayesian analysis provides a convenient setting for the estimation of complex generalized additive regression models (GAMs). Since computational power has tremendously increased in the past decade it is now possible to tackle complicated inferential problems, e.g., with Markov chain Monte Carlo simulation, on virtually any modern computer. This is one of the reasons why Bayesian methods have be...

One of the most crucial functions in the operation and control of power system is reactive power dispatch (RPD).A hybrid Big Bang–Big Crunch (HBB–BC) optimization algorithm which consists of A Big Bang– Big Crunch algorithm combined with particle swarm optimization (PSO) is proposed in this paper in order to solve optimal reactive power dispatch (ORPD) problem. The L-index of load buses is base...

26 7 JULY 2017 • VOL 357 ISSUE 6346 sciencemag.org SCIENCE Caruana’s GAMs are not as good as AIs at handling certain types of messy data, such as images or sounds, on which some neural nets thrive. But for any data that would fit in the rows and columns of a spreadsheet, such as hospital records, the model can work well. For example, Caruana returned to his original pneumonia records. Reanalyzi...

Abstract Glioblastoma (GBM) is an aggressive malignant adult brain tumor and characterized by poor prognosis survival outcome. Insufficient drug accumulation to the site development of monotherapy resistance are critical challenges overcome in combating GBM. Human induced neural stem cells (hiNSC) therapy promising due cells’ innate capability migrate tumors deliver therapeutics. We previously ...

A lack of transparency in machine learning models can limit their application. We show that analysis variance (ANOVA) methods extract interpretable predictive from them. This is possible because ANOVA decompositions represent multivariate functions as sums fewer variables. Retaining the terms summation involving only one or two variables provides an efficient method to open black box classifier...

With the increasing constraints on energy and resource markets non-decreasing trend in demand, need for relevant clean generation storage solutions is growing gradually reaching individual home. However, small-scale still an expensive investment 2022 risk/reward ratio not yet attractive enough homeowners. One solution homeowners to store excess individually but produce hydrogen mutual use. In t...