nonalcoholic fatty liver disease (nafld) is increasing in pediatric age group parallel to the growing prevalence of obesity and overweight all around the world. so changing in life style and   interventions on obesogenic environment is cornerstone of nafld therapy in obese children. some experts recommend that children and adolescents be encouraged to follow a low-fat, low-glycemic-index diet t...

Inhibiting angiogenesis is a promising strategy for treatment of cancer and several other disorders, including age-related macular degeneration. Major progress towards a treatment has been achieved over the past few years, and the first antiangiogenic agents have been recently approved for use in several countries. Therapeutic angiogenesis (promoting new vessel growth to treat ischaemic disorde...

The mechanism for the basal targeting of the Miranda (Mira) complex during the asymmetric division of Drosophila neuroblasts (NBs) is yet to be fully understood. We have identified conserved Phosphotyrosyl phosphatase activator (PTPA) as a novel mediator for the basal localization of the Mira complex in larval brain NBs. In mutant Ptpa NBs, Mira remains cytoplasmic during early mitosis and its ...

Cell contractility and migration by integrins depends on precise regulation of protein tyrosine kinase and Rho-family GTPase activities in specific spatiotemporal patterns. Here we show that protein tyrosine phosphatase PTP1B cooperates with β3 integrin to activate the Src/FAK signalling pathway which represses RhoAmyosin-dependent contractility. Using PTP1B null (KO) cells and PTP1B reconstitu...

Patients with suspected complications of gallstone disease should be evaluated for alternative diagnoses, as well as complications of gallstones such as pancreatitis and cholangitis. Laboratory evaluation for all these patients should include a complete blood count, basic serum chemistries, liver function tests, serum amylase and lipase, and urinalysis. A urine pregnancy test should always be p...

A long-standing question in the planetary sciences asks what the Earth is made of. For historical reasons, volatile-depleted primitive materials similar to current chondritic meteorites were long considered to provide the `building blocks' of the terrestrial planets. But material from the Earth, Mars, comets and various meteorites have Mg/Si and Al/Si ratios, oxygen-isotope ratios, osmium-isoto...