Ogasawara K, Terada T, Asaka J, Katsura T, Inui K. Hepatocyte nuclear factor-4 regulates the human organic anion transporter 1 gene in the kidney. Am J Physiol Renal Physiol 292: F1819–F1826, 2007. First published March 6, 2007; doi:10.1152/ajprenal.00017.2007.—Human organic anion transporter 1 (OAT1, SLC22A6), which is localized to the basolateral membranes of renal tubular epithelial cells, p...

BACKGROUND Hepatocyte nuclear factor-1beta (HNF-1beta) is a critical transcription factor in pancreatic and renal development. Our previous report identified HNF-1beta mutations in 23/160 patients with unexplained renal disease. The most common phenotype is renal cysts, which is frequently associated with early-onset diabetes in the renal cysts and diabetes (RCAD) syndrome. HNF-1beta gene delet...

Guo, Hongtao, Junping Wei, Yusuke Inoue, Frank J. Gonzalez, and Paul C. Kuo. Serine/threonine phosphorylation regulates HNF-4 -dependent redox-mediated iNOS expression in hepatocytes. Am J Physiol Cell Physiol 284: C1090–C1099, 2003. First published December 4, 2002; 10.1152/ajpcell.00394.2002.—Nitric oxide (NO), endogenously synthesized by inducible NO synthase (iNOS), serves antioxidant and a...

Abstract Transition metal oxides (TMOs) are considered as promising anode materials for lithium-ion batteries in comparison with conventional graphite anode. However, TMO anodes suffer severe volume expansion during charge/discharge process. In this respect, a porous Fe 2 O 3 nanorod-decorated hollow carbon nanofiber (HNF) is designed via combined electrospinning and hydrothermal method followe...

We investigated the effect of diel variation in cell properties of picoplankton prey and the intrinsic grazing rhythm of heterotrophic nanoflagellates (HNF) on the diel periodicity of HNF grazing. To achieve this aim, 2-point dilution experiments with short incubation time were performed over 24 h in the South China Sea and Hong Kong (HK) coastal water to assess the prey cell properties and HNF...

Mutations in the gene encoding for the neurofilament light subunit (NF-L) are responsible for Charcot-Marie-Tooth (CMT) neuropathy type 2E. To address whether CMT2E disease is potentially reversible, we generated a mouse model with conditional doxycycline-responsive gene system that allows repression of mutant hNF-LP22S transgene expression in adult neurons. The hNF-LP22S;tTa transgenic (tg) mi...

Two novel compounds, 1α-methoxy-3β-hydroxy-4α-(3′,4′-dihydroxyphenyl)-1, 2,3,4-tetrahydronaphthalin (1) and 1α,3β-dihydroxy-4α-(3′,4′-dihydroxyphenyl)-1,2,3,4-tetrahydronaphthalin (2), were isolated along with six known compounds 3-8 from the rhizomes of Cyperus rotundus. This paper reports the isolation and full spectroscopic characterization of these new compounds by NMR, UV, IR and MS data.

HNF-4 (hepatocyte nuclear factor 4) is a key regulator of liverspecific gene expression in mammals. We have shown previously that the activity of the human APOC3 (apolipoprotein C-III) promoter is positively regulated by the anti-inflammatory cytokine TGFβ (transforming growth factor β) and its effectors Smad3 (similar to mothers against decapentaplegic 3) and Smad4 proteins via physical and fu...