Two new eudesmane sesquiterpenes, 2alpha-hydroxy pterodontic acid (1) and pterodolide [3alpha-(2-methyl-2,3-epoxy)-butyric-4alpha-acetoxy-8beta-ethoxy eudesma-7(11)-en-8alpha,12-olide (2), along with five known compounds (3-7) were isolated from the aerial parts of Laggera pterodonta. Their structures were elucidated on the basis of spectroscopic methods. The immunosuppressive activity of the i...

PURPOSE Iron deficiency remains a very common nutritional problem despite the improvement in nutrition and increased understanding of methods for its prevention. Thus, we try to create a new method for screening iron nutrition through infant nutrition history. METHODS Among the children who visited Inha University Hospital from March 2006 to July 2012, 181 children with iron deficiency anemia...

MOTIVATION We address the following question: Does inhibition of the expression of a gene X in a cellular assay affect the expression of another gene Y? Rather than inhibiting gene X experimentally, we aim at answering this question computationally using as the only input observational gene expression data. Recently, a new statistical algorithm called Intervention calculus when the Directed acy...

BACKGROUND The aim of this study was to investigate the urine levels of human kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and liver-type fatty acid-binding protein (L-FABP) in children with iron-deficiency anemia (IDA). MATERIAL AND METHODS Thirty-five children with IDA and 32 matched healthy controls were recruited....

In this paper, we study the performance of various IDA*-style searches and investigate methods to improve their performance by predicting in each stage the threshold to be used for pruning. Without loss of generality, we consider minimization problems in this paper. We rst present three models to approximate the distribution of the number of search nodes by lower bounds: exponential, geometric ...

BACKGROUND/AIMS Helicobacter pylori (H. pylori) infection appears to subvert the human iron regulatory mechanism and thus upregulates hepcidin, resulting in unexplained iron-deficiency anemia (IDA). We evaluated serum prohepcidin levels before and after eradication of H. pylori in IDA patients to assess whether it plays a role in IDA related to H. pylori infection. METHODS Subjects diagnosed ...

Direct lineage reprogramming through genetic-based strategies enables the conversion of differentiated somatic cells into functional neurons and distinct neuronal subtypes. Induced dopaminergic (iDA) neurons can be generated by direct conversion of skin fibroblasts; however, their in vivo phenotypic and functional properties remain incompletely understood, leaving their impact on Parkinson's di...

This longitudinal study investigated the rates of iron-deficiency (ID) and iron-deficiency anemia (IDA) among prenatally cocaine-exposed and nonexposed two- and four-year-old children and assessed their relationships to neurodevelopmental outcomes. The sample consisted of 143 two-year-old (70 exposed and 73 nonexposed) and 274 four-year-old (139 exposed and 135 nonexposed) low socioeconomic sta...

Epidemiology In the developed world, 2-5% of adult men and postmenopausal women have IDA. [4] Iron deficiency and IDA are common in young children. [5] Iron deficiency is the most common cause of anaemia in pregnancy worldwide; severe anaemia can have very serious consequences for mothers and babies. [6] Premenopausal women have a higher incidence of IDA because of heavy menstrual blood losses ...