Nitroxyl (HNO) displays pharmacological and therapeutic actions distinct from those of its redox sibling nitric oxide (NO(•)). It remains unclear, however, whether the vasoprotective actions of HNO are preserved in disease. The ability of the HNO donor isopropylamine NONOate (IPA/NO) to induce vasorelaxation, its susceptibility to tolerance development, and antiaggregatory actions were compared...

UNLABELLED Oxidative stress plays an important role in diabetes mellitus (DM)-associated vascular injury. DM is an important risk factor for erectile dysfunction. Functional and structural changes in internal pudendal arteries (IPA) can lead to erectile dysfunction. We hypothesized that downregulation of nuclear factor E2-related factor 2 (Nrf2), consequent to increased nicotinamide adenine din...

Aspergillus fumigatus, a thermotolerant fungus, is the main causative agent of invasive pulmonary aspergillosis (IPA) in immunocompromised patients that is associated with high mortality rates. Early diagnosis of IPA is crucial for mortality reduction and improved prognosis. An experimental inhalational model of IPA was developed in rats and the efficacy of three biomarkers, namely β-D-glucan (...

Background: Invasive pulmonary aspergillosis (IPA) is an infection often occurring in neutropenic patients and has high mortality rates. In recent years, it has been reported that the incidence of IPA has also increased in patients with chronic obstructive pulmonary disease (COPD). The purpose of this study is to investigate the clinical and demographic characteristics and treatment responses o...

The variety described here is representative of colloquial Assamese spoken in the eastern districts of Assam.1 Assam is a North-Eastern state of India, therefore Assamese and creoles of Assamese like Nagamese are spoken in the different North-Eastern states of Nagaland, Arunachal Pradesh, Meghalaya, and also the neighbouring country of Bhutan. Approximately 15 million people speak Assamese in I...

Pitjantjatjara is a dialect of the Western Desert Language (WDL) of central Australia (Douglas 1958). The Western Desert Language is a member of the south-west Pama-Nyungan group. Together with Warnman, it forms the Wati sub-group. It is spoken by 4000–5000 people, and covers the widest geographical area of any language in Australia, stretching from Woomera in central northern South Australia, ...

Recently there has been a considerable interest in the application of Infinitesimal Perturbation Analysis (IPA) to continuous queues, where its sample derivatives (gradients) were shown to be unbiased for a large class of systems. This paper extends the investigation to a class of hybrid Petri nets, where the special algebraic structure of continuous transitions yields simple algorithms for the...

the purpose of this paper is to improve supply chain relationships in iranian small and medium-sized enterprises (smes) in automotive parts industry. for this reason, an importance-performance analysis (ipa) has been employed to categorized supply chain relationships metrics. also, the questionnaire method is used for gathering information. the paper identified thirteen supply chain relationshi...

A detailed process characterization of SML electron beam resist for high-aspect-ratio nanopatterning at high sensitivity is presented. SML contrast curves were generated for methyl isobutyl ketone (MIBK), MIBK/isopropyl alcohol (IPA) (1:3), IPA/water (7:3), n-amyl acetate, xylene, and xylene/methanol (3:1) developers. Using IPA/water developer, the sensitivity of SML was improved considerably a...

A 67-year-old female with rheumatoid arthritis and asthma-chronic obstructive pulmonary disease overlap syndrome was admitted for drug-induced hypersensitivity syndrome (DIHS) caused by salazosulfapyridine. Human herpes virus 6 (HHV-6) variant B was strongly positive on peripheral blood. Multiple cavities with ground grass opacities rapidly emerged predominantly in the upper and middle lobes. S...