The Hippo pathway is an evolutionarily conserved signaling module that plays multiple roles in embryonic development. Components of the pathway, which includes a kinase cascade and a downstream complex composed of YAP and TEAD transcription factors, are dysregulated in a significant fraction of human cancers. In this issue of Genes & Development, Liu-Chittenden and colleagues (pp. 1300-1305) us...

We establish an asymptotic connection between vanishing r’th power distortion and shrinking cell diameters for vector quantizers with convex cells. Appears in IEEE Transaction on Information Theory, vol. 24, no. 3, pp. 1303-1305, 1996. ∗Andrew Nobel is with the Department of Statistics, University of North Carolina, Chapel Hill, NC 27599-3260. This work was completed while he was a Beckman Inst...

This article assesses the extent to which academic community engaged with climate change in Central Asia between 1991 and 2021. The finds that has been neglected field of area studies. Out a total 13,488 journal articles eight key journals for research, only 33 (0.24%) were on or related topic. Climate similarly at events 17 studies associations. 1305 conference panels, none was focused change....

BACKGROUND AZD1305 is an investigational antiarrhythmic agent for management of atrial fibrillation. It blocks various cardiac ion currents at different potencies and has atrial-predominant electrophysiological effects. We investigated the electrophysiological and proarrhythmic effects of AZD1305 versus dofetilide in dogs with chronic complete atrioventricular block and myocardial hypertrophic ...

We report the details of an XMM observation of the cluster of galaxies Zw 1305.4+2941 at the intermediate redshift of z=0.241, increasing the small number of interesting X-ray constraints on properties of ∼ 3 keV systems above z=0.1. Based on the ∼ 45ks XMM observation, we find that within a radius of 228 kpc the cluster has an unabsorbed X-ray flux of fX = (2.07± 0.06)× 10 −13 ergs cm s, a tem...