objective(s): p-glycoprotein (p-gp) is an efflux protein, the overexpression of which has been associated with multidrug resistance in various cancers. although sirna delivery to reverse p-gp expression may be promising for sensitizing of tumor cells to cytotoxic drugs, the therapeutic use of sirna requires effective carriers that can deliver sirna intracellularly with minimal toxicity on targe...

صخلملا This study was designed to evaluate the cytotoxic effect ةتبن قارولأ يئاملا صلختسملا ةيمس ىدم ميقتل ةساردلا هذه تممص ايلاخ ضر MDA-MB231 و FaDu ةدملل ةيناطرسلا ايلاخلا ةجلا يف تابارطضاب صلختسملا اذهب لختسم ص ملا ةتبن قارولأ يئا © 2009 Jordan Journal of Biological Sciences. All rights reserved

fcεri, the high affinity receptor for ige plays a critical role in triggering the allergic reactions. it is responsible for inducing mast cell degranulation and deliberation of allergy mediators when it is aggregated by allergen and ige complexes. fcεri on the mast cells consists of three subunits; α chain directly binds ige, β chain and dimmer of γ chains together mediate intracellular signali...

Despite the great therapeutics potential, sustained release of small interfering RNA (siRNA) remains a challenge. Development siRNA nanoparticle provides possibility to further enhance therapeutic efficacy in gene-based therapy. Herein, we present new system based on encapsulation siRNA/chitosan-methacrylate (CMA) complexes into liposomes form UV crosslinkable Nanolipogels (NLGs) with siRNA-rel...

فوس لا اذ ه يف مدقن ثحب ماظن اً ً لاما آ لع فرعتلل ى تاملآ ) ةي سرافلا ة يطخلا قيلعت سن ( ب ا مادختس ةر يغتملا تلااحلا لوطو ةرمتسملا تادهاشملا فثا كتو يفخلا فوآرام ليدوم (CDVDHMM) . يفو ة لحرم لع لوصحلاو زيو نلا ءا غلإو يرنيا ب تا يلمع د عب ة مدقملا ميد قتلا ى ءازجلأا لا مادخت سا مت ي ةلصتم ةديدج ةيمزراوخ رئاسو طاقنلاو طباهلاو دعاصلا فشكل ءازجلأا يسيئرلا ريوصتلا نم اهبطشو ةيوناثلا . مث ذيفنت متي...