There has been a major revolution in the management of patients with myeloproliferative neoplasms (MPN), and in particular those with myelofibrosis and extensive splenomegaly and symptomatic burden, after the introduction of the JAK1 and JAK2 inhibitor ruxolitinib. The drug also has been approved as second-line therapy for polycythemia vera (PV). However, the therapeutic armamentarium for MPN i...

The nationwide statistical analysis of each disease of classical myeloproliferative neoplasm (MPN) in Korea has not been reported yet. To this end, we have analyzed incidence rates, survival rates and treatment pattern of polycythemia vera (PV), primary myelofibrosis (MF) and essential thrombocythemia (ET) using Korea National Cancer Incidence Database (KNCIDB) and Health Insurance Review and A...

The study was conducted to determine the coliform content of shellfish Anadara antiquata from three selected areas of Davao Gulf. One shot sampling was employed in the study and it was conducted within the month of February, 2010. Test for coliform and fecal coliform was done using the multiple-tube fermentation technique through the presumptive, confirmed and fecal coliform test. Total Colony ...

Analysis of 100 bagged lettuce and spinach samples showed mean total bacterial counts of 7.0 log(10) CFU/g and a broad range of < 4 to 8.3 log10 CFU/g. Most probable numbers (MPN) of > or = 11,000/g coliforms were found in 55 samples, and generic Escherichia coli bacteria were detected in 16 samples, but no E. coli count exceeded 10 MPN/g.

Air memiliki peranan yang sangat besar salah satunya untuk kebutuhan biologisnya, yaitu bertahan hidup. Masalah utama dihadapi berkaitan dengan sumber daya air adalah kualitas air. Penentuan secara mikrobiologi dilakukan Most Probable Number (MPN) Test. Penelitian ini menggunakan 3 sampel sumur, dalam kemasan, dan sungai. sumur mengandung Coliform Escherichia coli jumlah sama 14 MPN/100 mL. Pad...

Janus kinase-signal transducer and activator of transcription (JAK/STAT) signalling, pivotal in Philadelphia-negative (Ph-ve) myeloproliferative neoplasm (MPN), is negatively regulated by molecules including SOCSs, CISH and SHP1. SOCS1, SOCS2 and SOCS3 methylation have been studied in MPN with discordant results. Herein, we studied the methylation status of SOCS1, SOCS2 and SOCS3, CISH and SHP1...

BACKGROUND The JAK2 V617F mutation has been noted in the cases of polycythemia vera, essential thrombocythemia, and primary myelofibrosis patients. This mutation occurs less frequently in acute myeloid leukemia (AML) and other hematologic diseases, such as myelodysplastic syndrome (MDS); myelodysplatic syndrome/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U); and refractory anemia with ...

We have established a new method of HPLC analysis for the rapid separation from human serum and the quantification of 4-O-methylpyridoxine (MPN), which is contained in Ginkgo biloba seeds, and which, when consumed in large amounts, causes vomiting and convulsions. As a result of using IPCC-MS3 (GL Science, Tokyo, Japan), an ion-pair reagent, in the mobile phase, we succeeded in separating MPN i...

mpns including a heterogeneous group of clonal or oligoclonal hamtopathies characterized by proliferation and accumulation of mature myeloid cells. jak2 tyrosine kinase mutation is the most common molecular lesion identified in 90% of cases. jak2 is involved in epo signaling pathway, and mutations in it lead to epo-independent spontaneous phosphorylation. most tyrosine kinase inhibitors (tki) a...

Bivalve molluscs are a good source of high quality protein and perform important ecological functions. Their ability to bioaccumulate materials in their soft tissues makes them suitable aquatic species for biomonitoring environmental conditions. The discharge treated untreated sewage into the bivalve-growing areas is concern. aim this study was investigate prevalence bacterial microbiota shellf...