Congestive heart failure (CHF) is a major public health problem in developed countries.1–3 It is a significant burden to patients, healthcare providers, and society.2–4 Several hospital-based reports have documented that a high proportion of patients with CHF have normal left ventricular (LV) systolic function,5 and 4 different epidemiological investigations further confirmed that nearly half o...

BACKGROUND Understanding of cardiac outflow tract (OFT) remodeling is essential to explain repositioning of the aorta and pulmonary orifice. In wild type embryos (E9.5-14.5), second heart field contribution (SHF) to the OFT was studied using expression patterns of Islet 1, Nkx2.5, MLC-2a, WT-1, and 3D-reconstructions. Abnormal remodeling was studied in VEGF120/120 embryos. RESULTS In wild typ...

The background and purpose Diastolic and systolic heart failure (DHF and SHF) are the different clinical subsets. Because many heart failure patients have sleep apnea syndrome (SAS), oxygen supply improves the patient’s prognosis. Thus, the purpose of this study was to compare the effects of oxygen treatment for premature ventricular contractions (PVCs) suppression in patients between DHF and S...

The ground state properties of the nuclei are generally calculated using two different methods, namely Skyrme and Gogny force methods. We have nucleon densities Copper isotopes by Hartree-Fock-Skyrme (using Woods-Saxon Potential) (SHF-WS), Harmonic Oscillator (SHF-HO), Hartree-Fock-Bogolyubov-Skyrme (HFB-S) Hartree-Fock-Bogolyubov-Gogny (HFB-G) In first rms (root mean square) radii for both pro...

An ascending aortic aneurysm (AscAA) is a life-threatening disease whose molecular basis is poorly understood. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV), which is associated with AscAA. Here, we describe a potentially novel role for Notch1 in AscAA. We found that Notch1 haploinsufficiency exacerbated the aneurysmal aortic root dilation seen in the Marfan syndrome mouse...

This study reports on the EPR of C r 5 + and C u 2 + ions, introduced by solidand liquid-state reactions with the synthetic zeolites 3A, 4A and 5A, and the natural zeolite clinoptilolite. C r 3 + was oxidized to Cr 5 + in the samples, the coordination around Cr 5 + being square pyramidal. Superhyperfine (shf) interaction of Cr with A1 nucleus was observed in both solidand liquid-stateintroduced...

Rapid arrhythmia (RA) is a major complication of severe heart failure (SHF). Treatment with anti-arrhythmic drug amiodarone though improves the myocardial blood supply and suppress arrhthmia, its clinical application unsatisfactory. Amiodarone combined another class II antiarrhythmic drug, esmolol shows rapid onset good efficacy. Here, we studied effects in (SHF) effect on TGF-β1, APN PIIINP. A...

Rationale: Loss of Tbx1 and decrease of retinoic acid (RA) synthesis result in DiGeorge/velocardiofacial syndrome (DGS/VCFS)-like phenotypes in mouse models, including defects in septation of the outflow tract of the heart and anomalies of pharyngeal arch– derived structures including arteries of the head and neck, laryngeal–tracheal cartilage, and thymus/parathyroid. Wild-type levels of T-box ...