Progress in DNA-encoded chemical library synthesis and screening crucially relies on the availability of DNA-compatible reactions, which proceed with high yields excellent purity for a large number possible building blocks. In past, experimental conditions have been presented execution Suzuki Sonogashira cross-coupling reactions on-DNA. this article, our aim was to optimize comparing results pr...

DNAzymes have attracted increasing interest in developments of gene tools, therapies, and biosensors. Among them, G-quadruplexes are widely used as the key structure elements to activate catalytic competency specific cofactors, such hemin, but there is a great demand diversify using other more straightforward DNA structures fully matched duplex (FM-DNA). However, perfect base pairs limit DNAzym...

The interaction between isatin-β-thiosemicarbazone (IBT) and calf thymus DNA (CT-DNA) was investigated in physiological buffer (pH 7.4) using Neutral Red (NR) dye as a spectral probe by UV–Vis absorption and fluorescence spectroscopy, as well as viscosity measurements. The IBT is stabilized by intercalation in the DNA ( K [IBT –DNA] =1.03×105 M−1), and displaces the NR dye from the NR–DNA comple...

The interaction between isatin-β-thiosemicarbazone (IBT) and calf thymus DNA (CT-DNA) was investigated in physiological buffer (pH 7.4) using Neutral Red (NR) dye as a spectral probe by UV–Vis absorption and fluorescence spectroscopy, as well as viscosity measurements. The IBT is stabilized by intercalation in the DNA ( K [IBT –DNA] =1.03×105 M−1), and displaces the NR dye from the NR–DNA comple...

Abstract Substantial evidence has shown that overexpression of the inhibitor apoptosis protein (IAP) survivin in human tumors correlates significantly with treatment resistance and poor patient prognosis. Survivin serves as a radiation factor impacts DNA damage response by interacting DNA-dependent kinase (DNA-PKcs). However, complexity, molecular determinants, functional consequences this inte...