PURPOSE Topiramate is an effective anti-epileptic drug and can be associated with increased risk for urolithiasis because of its effects on acid-base profile. Evidences that supported an association of topiramate and urolithiasis were limited to case reports or series. We investigated the association of topiramate and urolithiasis in a nationwide population-based cohort study. METHODS We anal...

The recent modifications that Legislative Decree No. 1377 has brought and its effect on institutions as well the modalities in which compliance with food institution is sought leads us to analyze again viability of regulation respective regulations also way they have been applied national  reality. Only an adequate rethinking will it create desired by creators society role played State.

We have evaluated the use of allele-specific PCR (AS PCR) on DNA pools as a tool for screening inherited genetic variants that may be associated with risk of adult acute myeloid leukemia (AML). Two DNA pools were constructed, one of 444 AML cases, and another of 823 matched controls. The pools were validated using individual genotyping data for GSTP1 and LTalpha variants. Allele frequencies for...