We examined the effects of chronic centrally administered leptin on the glucose metabolism of streptozotocin-induced diabetic (STZ-D) rats, a model for insulin-dependent diabetes mellitus. When 3 microg.rat(-1).day(-1) of leptin was infused into the third ventricle for 6 consecutive days (STZ-LEP), STZ-D rats became completely euglycemic. The effect was not seen when the same dosage was adminis...

Mechanistic studies examining the effects of Type 1 diabetes mellitus (T1DM) on skeletal muscle have largely relied on streptozotocin-induced diabetic (STZ) rodents. Unfortunately, characterization of diabetic myopathy in this model is confounded by the effects of streptozotocin on skeletal muscle independent of the diabetic phenotype. Here we define adolescent diabetic myopathy in a novel, gen...

OBJECTIVE N-(2-hydroxyethyl)-nicotinamide nitrate (nicorandil) is a unique anti-anginal agent, reported to act as both an ATP-sensitive K(+) channel opener (PCO) and a nitric oxide donor. It also has an anti-oxidant action. We examined the effects of nicorandil on streptozotocin (STZ)-induced islet beta-cell damage both in vivo and in vitro. DESIGN AND METHODS STZ-induced diabetic Brown Norwa...

Background: Alzheimer's disease (AD) is a neurodegenerative illness that causes memory loss and cognitive impairment. For illnesses, the therapeutic properties healthy advantages of brewed coffee (BC) intake have been widely explored. Objectives: This research aimed to look into findings sub-chronic BC administration on long-term potentiation (LTP) as model synaptic plasticity supports function...

The present study was conducted to examine the effect of administration of conophylline (CnP) and betacellulinδ4 (BTCδ4) on the β-cell mass in neonatal streptozotocin-treated rats (neonatal sTz rats). sTz (100 μg/g) was injected into neonatal rats, and then CnP (2 μg/g) and/or BTCδ4 (200 pmol/g) were administered to neonatal sTz rats for 1 week. The plasma glucose concentration was monitored, a...

Streptozotocin (STZ) is a diabetogenic agent extensively used to induce diabetes and to study complications including diabetic peripheral neuropathy (DPN). While studying the influence of transient receptor potential vanilloid 1 (TRPV1) on DPN in the STZ-induced diabetic mouse model, we found that a proportion of STZ-treated mice was nondiabetic but still exhibited hyperalgesia. To understand t...

We compared the effects of streptozotocin (STZ) treatment on serum cholesterol and lipoprotein levels in spontaneously hyperlipidemic rats (HLR), a hereditary hyperlipidemic model animal, with those in Sprague-Dawley rats (SDR). The body weight of control SDR and HLR were increased continuously for 30 days. Both SDR and HLR lost their body weight after STZ administration. Glucose levels of SDR ...