نتایج جستجو برای: رزوراترول ucp 1
تعداد نتایج: 2753125 فیلتر نتایج به سال:
The studies about the effect of exercise training on expression of Uncoupling Protein 1 (UCP-1) in different adipose depots were few. Thus, the purpose of this study was to investigate the effect of eight weeks endurance training on expression of this gene in retroperitoneal adipose tissue of wistar rats. Methods: 20 rats were purchased, and were divided randomly into two g...
مقدمه و هدف: تغییر فنوتیپ بافت چربی در اثر تمرینات ورزشی تئوری جدیدی است که اخیرا مطرح شده است و هورمون آیریزین که در سال 2012 کشف گردیده است در این عمل نقش مهمی ایفا میکند. با این وجود شناسایی سازوکار مولکولی آن در حال بررسی است. هدف از پژوهش حاضر بررسی تأثیر تمرین تناوبی شدید (HIIT) بر میزان آیریزین پلاسما، پروتئین جفت نشده -1 (UCP-1) چربی زیر پوستی و شاخص مقاومت انسولینی در رتهای نر چاق اس...
UCP-2 shows an important role in modulating of mitochondrial membrane potential and cell apoptosis. Whether or not UCP-2 could been a critical factor in preventing AAA formation is not known. We report that UCP-2 protein and mRNA expression were significantly higher in Ang-Ⅱ-induced AAA of mice. The incident rate of AAA in UCP-2-/-ApoE-/- mice after Ang-Ⅱtreatment was higher than the rate in th...
The role of brown adipose tissue in total energy balance and cold-induced thermogenesis was studied. Mice expressing mitochondrial uncoupling protein 1 (UCP-1) from the fat-specific aP2 gene promoter (heterozygous and homozygous aP2-Ucp transgenic mice) and their nontransgenic C57BL6/J littermates were used. The transgenic animals are resistant to obesity induced by a high-fat diet, presumably ...
PURPOSE To evaluate CD4(+) helper functions and antitumor effect of promiscuous universal cancer peptides (UCP) derived from telomerase reverse transcriptase (TERT). EXPERIMENTAL DESIGN To evaluate the widespread immunogenicity of UCPs in humans, spontaneous T-cell responses against UCPs were measured in various types of cancers using T-cell proliferation and ELISPOT assays. The humanized HLA...
Skeletal muscle uncoupling protein 2 and 3 (UCP-2 and UCP-3) mRNA levels are increased during calorie restriction in lean and nondiabetic obese subjects. In this work, we have investigated the effect of a 5-day hypocaloric diet (1,045 kJ/day) on UCP-2 and UCP-3 gene expression in the skeletal muscle of type-2 diabetic obese patients. Before the diet, UCP-2 and UCP-3 mRNA levels were more abunda...
The HIB 1B cell line, derived from a brown fat tumor of a transgenic mouse, is the first established brown adipocyte cell line capable of expressing the brown fat-specific mitochondrial uncoupling protein (UCP). UCP gene expression, which was virtually undetectable under basic conditions, was stimulated by acute catecholamine or cyclic AMP treatment to levels comparable to primary cultures of b...
BACKGROUND The ability of a scientist to maintain a continuous stream of publication may be important, because research requires continuity of effort. However, there is no data on what proportion of scientists manages to publish each and every year over long periods of time. METHODOLOGY/PRINCIPAL FINDINGS Using the entire Scopus database, we estimated that there are 15,153,100 publishing scie...
The factors that regulate gene expression of uncoupling proteins 2 and 3 (UCP-2 and UCP-3) in skeletal muscle are poorly understood, but both genes are clearly responsive to the metabolic state of the organism. Therefore, we tested the hypothesis that denervation and acute and/or chronic exercise (factors that profoundly affect metabolism) would alter UCP-2 and UCP-3 gene expression. For the de...
UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase.
Uncoupling protein 3 (UCP-3), a member of the mitochondrial transporter superfamily, is expressed primarily in skeletal muscle where it may play a role in altering metabolic function under conditions of fuel depletion caused, for example, by fasting and exercise. Here, we show that treadmill running by rats rapidly (30 min) induces skeletal muscle UCP-3 mRNA expression (sevenfold after 200 min)...
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