Strategic performance management (SPM) has become an important vehicle for business management in today’s turbulent business environment. SPM has in recent years attracted much research interest from the side of both scientists and policy-makers. This interest is warranted because of the fundamental transformations (e.g. increased competition, changes in the regulatory environment, the impact o...

Polyamines are absolute requirements for cell growth. When in excess, Pseudomonas aeruginosa possesses six γ-glutamylpolyamine synthetases (GPSs) encoded by the pauA1-pauA7 genes to initiate polyamine catabolism. Recently, the pauA2 mutant was reported to lose the capability to grow on spermine (Spm) and spermidine (Spd) as sole carbon and nitrogen sources. Although this mutant grew normally in...

IMPORTANCE Little is known about survival after a diagnosis of a second or higher-order (multiple) primary melanoma, and no study has explored survival in a population-based sample that included patients with single primary melanomas (SPMs) and multiple primary melanomas (MPMs) of any stage. Because people with a first primary melanoma are known to have an increased risk of being diagnosed with...

The nucleotide excision repair (NER) pathway is central in response to damage induced by environmental carcinogens. Efficiency of this pathway, probably genetically determined, may modulate individual risk of developing squamous cell carcinoma of the head and neck (SCCHN) as well as second primary malignancy (SPM) after the index tumor. We hypothesized that common non-synonymous and regulatory ...

Despite a real risk of overturning, for the Self-Propelled agricultural Machinery (SPM) the ROPS approach to protect the driver is rather recent. Due to the several SPM categories available on the market, characterized by very different mass, dimension and working functions, the fitting of a ROPS and consequently the check of its strength is complicated. The SPM could be preliminarily divided i...

The accurate measurement of suspended particulate matter (SPM) concentrations in coastal waters is of crucial importance for ecosystem studies, sediment transport monitoring, and assessment of anthropogenic impacts in the coastal ocean. Ocean color remote sensing is an efficient tool to monitor SPM spatio-temporal variability in coastal waters. However, near-shore satellite images are complex t...

The Sand Pile Model (SPM) and its generalization, the Ice Pile Model (IPM), originate from physics and have various applications in the description of the evolution of granular systems. In this article, we deal with the enumeration and the exhaustive generation of the accessible configuration of the system. Our work is based on a new recursive decomposition theorem for SPM configurations using ...

A series of SPM VIII analogs were synthesized to investigate the effect of the amino acid moiety on the antitumor activity. The L-threonine analog and the glycylglycine analog of SPM VIII showed much higher cytotoxicity to P388 murine leukemia cells (IC50 5.8 nM and 0.11 nM, respectively) than SPM VIII (IC50 25nM). However, replacement of the glycine moiety with other amino acids greatly reduce...

This paper proposes a sequential pattern mining (SPM) algorithm in large scale uncertain databases. Uncertain sequence databases are widely used to model inaccurate or imprecise timestamped data in many real applications, where traditional SPM algorithms are inapplicable because of data uncertainty and scalability. In this paper, we develop an efficient approach to manage data uncertainty in SP...

Previous studies have led to the hypothesis that some proteins of the postsynaptic membrane are locally synthesized at postsynaptic sites. To evaluate this hypothesis, synaptosome fractions that included fragments of dendrites were allowed to incorporate labeled amino acid into protein. The labeled synaptosomes were then subfractionated to the level of the synaptic plasma membrane (SPM) and the...