background: there are no data on familial aggregation of colorectal cancer (crc) in northeastern iran. the aim of this study was to determine the prevalence of early-onset crc and patients suspected for hereditary non-polyposis colorectal cancer (hnpcc) based on the clinical criteria in this area. materials and methods: documents were collected from two hospitals in mashhad regarding 326 inpati...

conclusions we have found significant associations between lifestyle factors (alcohol consumption and smoking) and mental health problems (depression and insomnia) and crc screening uptake. to improve overall crc screening uptake in the us, it is important to consider racial differences in predictors and tailor appropriate interventions to each racial/ethnic group. background mortality from col...

background: colorectal cancer (crc) is the second cause of cancer-related deaths worldwide. there have been several studies reporting the proximal tumor shift, especially in western countries. in the present study, we investigated the clinicopathologic and anatomical distributions of colorectal tumors in iranian crc patients. materials and methods: in this retrospective cohort study,258 patient...

Colorectal cancer (CRC) is one of the common causes of cancer death in Iranian population. Both genetic and epigenetic changes have been implicated in CRC pathogenesis. DACT2 gene as one of the WNT signaling pathway inhibitor was shown to display tumor suppressor activity in many cancers. The aim of present study was to investigate the methylation status of DACT2 gene and its ...

Background: As critical regulators, lncRNAs have attracted attention from researchers for diagnostic, prognostic, and therapeutic purposes in human carcinogenesis via interfering with mRNAs such as EZH2. Nevertheless, the potent roles and molecular mechanisms of these RNAs in CRC are not clearly known. Methods: In this study, the tissue expressions of lncRNA MINCR and EZH2 mRNA between colorect...

this study was carried out to analyze certain epidemiological variations in iranian patients with colorectal cancer. (crc): from march 1981 up to march 1993, 103 patients were analyzed retrospectively for age, gender, marital state, job, nutritional habits, presenting symptoms and histopathological features. most of the patients with colorectal cancer were male, age range 20-75 (mean 56), 25.4 ...

Background and Objective: Colorectal cancer (CRC) is one of the most prevalent malignancies in the world. The early detection of CRC is not only a simple process, but it is also the key to its treatment. Given that data mining algorithms could be potentially useful in cancer prognosis, diagnosis, and treatment, the main focus of this study is to measure the performance of some data mining class...