OBJECTIVE Nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. Numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. The aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of Nigella sativa oil in patients with rheumatoid arth...

BACKGROUND Hashimoto's thyroiditis is an autoimmune disorder and the most common cause of hypothyroidism. The use of Nigella sativa, a potent herbal medicine, continues to increase worldwide as an alternative treatment of several chronic diseases including hyperlipidemia, hypertension and type 2 diabetes mellitus (T2DM). The aim of the current study was to evaluate the effects of Nigella sativa...

caused by thioacetamide (20 mg/kg body weight) in albino rats for a period of eight week. A significant (p<0.05) improvement in the altered levels of bilirubin, albumin, total protein, alanine transaminase, alkaline phosphatase, γ-glutamyl transferase was observed after treatment with 10 ml/kg body weight of Nigella sativa oil. Antioxidant enzymes like catalase, superoxide dismutase glutathione...

Paracetamol (APAP-Acetaminophen) has been used extensively as antipyretic drug. The purpose of this study was to evaluate the ameliorative role of silymarin or/and Nigella sativa extract against APAP-induced hyperlipidemia in male mice at the biochemical, levels. The mice were divided into seven groups (10/group). The first group was served as control. While, the second group was treated with d...

PURPOSE The aim of this study was to determine the toxic effect of Nigella sativa powder on the liver function which was evaluated by measuring liver enzymes and through histopathological examination of liver tissue. METHODS Twenty four male Sprague Dawley rats were allotted randomly to four groups including: control (taking normal diet); low dose (supplemented with 0.01 g/kg/day Nigella sati...

OBJECTIVE Oxidative stress plays an important role in the etiology of diabetic complications. Diabetes impairs hippocampus neurogenesis, synaptic plasticity, and learning. The aim of this study was to investigate the effects of hydroalcoholic extract of Nigella sativa seed on oxidative stress in STZ-induced diabetic rats' hippocampus. MATERIALS AND METHODS Diabetes induced by 60 mg/kg STZ, i....