The formation of lymph nodes is a complex process crucially controlled through triggering of LTbetaR on mesenchymal cells by LTalpha(1)beta(2) expressing lymphoid tissue inducer (LTi) cells. This leads to the induction of chemokines to attract more hematopoietic cells and adhesion molecules to retain them. In this study, we show that the extravasation of the first hematopoietic cells at future ...

Skin conductance responses (SCR) are increasingly analyzed with model-based approaches that assume a linear and time-invariant (LTI) mapping from sudomotor nerve (SN) activity to observed SCR. These LTI assumptions have previously been validated indirectly, by quantifying how much variance in SCR elicited by sensory stimulation is explained under an LTI model. This approach, however, collapses ...

During fetal development, lymphoid tissue inducer cells (LTis) seed the developing lymph node and Peyer's patch anlagen and initiate the formation of both types of lymphoid organs. In the adult, a similar population of cells, termed lymphoid tissue inducer-like cells (LTi-like cells), supports the formation of organized gut-associated lymphoid tissue (GALT) in the intestine, including both isol...

In this paper we consider the servomechanism problem for SISO positive LTI systems. In particular, we solve the robust servomechanism problem of nonnegative constant reference signals for stable SISO positive unknown LTI systems with constant nonnegative unmeasurable disturbances under strictly nonnegative control inputs, using a clamping tuning regulator.

Although techniques for directly synthesising sampled-data (SD) compensators are available in the literature, feedback controller design is perhaps best understood in a purely continuous-time setting. As such, a feedback controller is often designed in the continuous-time domain and then discretised for digital implementation. It is important for the discretisation step involved to yield a SD a...

BACKGROUND Rocuronium produces injection pain in 50-80% of treated patients. Therefore, a variety of pretreatments have been attempted to reduce this issue. We evaluated the efficacy of 3 different doses of magnesium on the rocuronium injection pain and following hemodynamic changes by laryngoscopy and tracheal intubation (LTI). METHODS Two hundreds patients, ASA I and II, undergoing general ...

Lymphoid tissue development is initiated during embryogenesis by the migration of lymphoid tissue inducer (LTi) cells from the fetal liver to the periphery, where they induce the formation of lymph nodes and Peyer's patches. In the fetal liver, a subset of common lymphoid progenitors (CLPs) that expresses the integrin α4β7 gives rise to LTi cells, a process strictly dependent on the expression ...

We present a framework to synthesize lm 2 -stable control networks which are subject to delays and data dropouts. This framework can be applied to control systems which use “soft-real-time” cooperative schedulers and wired or wireless network feedback. The approach applies to passive plants and controllers that can be either linear, nonlinear, and (or) time-varying. This framework is based on f...