For the formation of lymph nodes and Peyer’s patches, lymphoid tissue inducer cells are crucial in triggering stromal cells to recruit and retain hematopoietic cells. Although LTi cells have been observed in fetal spleen, not much is known about fetal spleen development and the role of LTi cells in this process. Here we show that LTi cells collect in a periarteriolar manner in fetal spleen at t...

In this paper, the Linear Time Invariant (LTI) and Periodic (LTP) models of two different implementations DDSRF-PLL in presence voltage imbalance are derived analytically. The accuracy is investigated with time domain simulations, frequency scans, stability analysis. On top this, a guideline for properly choosing between LTI LTP assessment according to degree grid proposed. Furthermore, it reve...

We address the global stabilization of linear time-invariant (LTI) systems when the magnitude of the control input and its successive time derivatives, up to an order p∈N, are bounded by prescribed values. We propose a static state feedback that solves this problem for any admissible LTI systems, namely for stabilizable systems whose internal dynamics has no eigenvalue with positive real part. ...

There are three basic concepts behind the standard feedback optimization setup: the notion of a multi-input, multi-output (MIMO) linear time-invariant (LTI) finite order system, the notion of an internally stable feedback interconnection of two MIMO LTI systems, and the notion of a system norm. In addition, there is a concept of well-posedness of the resulting optimization problem, which has to...

This paper shows that the use of dynamic compensation based on generalized sampled-data hold hmdious (GSHF) can arbitrarily improve the gain margin for continuous-time mnminimum phase linear systems The GSHF compensator is a particular periodic digital contrdler mu& simpler than that used in [4]. The effect of sampling period on the gain margin is analyzed. Furthermore, it is proved that under ...

Linear time-periodic (LTP) dynamical systems frequently appear in the modeling of phenomena related to fluid dynamics, electronic circuits, and structural mechanics via linearization centered around known periodic orbits of nonlinear models. Such LTP systems can reach orders that make repeated simulation or other necessary analysis prohibitive, motivating the need for model reduction. We develo...

Here, we characterize a subset of ILC3s that express Neuropilin1 (NRP1) and are present in lymphoid tissues, but not in the peripheral blood or skin. NRP1+ group 3 innate lymphoid cells (ILC3s) display in vitro lymphoid tissue inducer (LTi) activity. In agreement with this, NRP1+ ILC3s are mainly located in proximity to high endothelial venules (HEVs) and express cell surface molecules involved...

The effects of annealing on the mechanical properties of polymer blends of poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) were investigated. The bending strength and modulus of PLA/PCL tend to increase due to crystallization of the PLA phase by annealing. The mode I fracture energy, J(in), of PLA/PCL decreases dramatically due to the suppression of the ductile deformation of the spheric...

This paper presents a State-space Model Interpolation of Local Estimates (SMILE) technique to compute linear parameter-varying (LPV) models for parameter-dependent systems through the interpolation of a set of linear time-invariant (LTI) state-space models obtained for fixed operating conditions. Since the state-space representation of LTI models is not unique, a suitable coherent representatio...