Functional interactions between dopamine D1-like receptors and NMDA subtype glutamate receptors have been implicated in the maintenance of normal brain activity and neurological dysfunction. Although modulation of NMDA receptor functions by D1 receptor activation has been the subject of extensive investigation, little is known as to how the activation of NMDA receptors alters D1 function. Here ...

GSK-3beta-dependent phosphorylation of cyclin D1 at Thr-286 promotes the nuclear-to-cytoplasmic redistribution of cyclin D1 during S phase of the cell cycle, but how phosphorylation regulates redistribution has not been resolved. For example, phosphorylation of nuclear cyclin D1 could increase its rate of nuclear export relative to nuclear import; alternatively, phosphorylation of cytoplasmic c...

When D: E → F is a linear differential operator of order q between the sections vector bundles over manifold X dimension n, it defined by bundle map Φ: Jq(E) F=F0 that may depend, explicitly or implicitly, on constant parameters a, b, c, ... . A “direct problem” to find generating compatibility conditions (CC) in form an D1: F0 F1. D involutive, when corresponding system Rq = ker (Φ) this proce...

A novel series of pyrazole derivatives containing imidazo[1,2-a]pyridine D1-D8 moiety has been synthesized. The reaction 2-aminopyridine with 4-phenylphenacyl bromide and 4-bromophenacyl gave the products A1, respectively. These then reacted DMF POCl3 to obtain new aldehyde B B1. two aldehydes were condensed various acetophenone substitutes yield corresponding chalcone C1-C10. Following this, c...

A field experiment was conducted to examine the effects of different depths ofnitrogen (N) fertiliser placements on N accumulation, remobilisation and NO3−-Ncontent in soil of rainfed wheat. Nitrogen was applied on the surface (D1) and inthe 10 cm (D2), 20 cm (D3) and 30 cm (D4) soil layers from 2010 to 2012.Compared with D1 and D2, D3 and D4 treatments obtained significant higher Ndistribution...

The objective of this study was to search for single nucleotide polymorphism (SNP)-type polymorphisms in the dopamine D1 receptor in West Azerbaijani native chicken and look for their association with egg production and body weight traits of chickens by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP). For this purpose 180 blood samples were taken from nativ...

There is increasing evidence that p21(Cip1) and p27(Kip1) are requisite positive regulators of cyclin D1.CDK4 assembly and nuclear accumulation. Both Cip and Kip proteins can promote nuclear accumulation of cyclin D1, but the underlying mechanism has not been elucidated. We now provide evidence that p21(Cip1) promotes the nuclear accumulation of cyclin D1 complexes via inhibition of cyclin D1 n...

Cyclin D1 is an important molecular driver of human breast cancer but better understanding of its oncogenic mechanisms is needed, especially to enhance efforts in targeted therapeutics. Currently, pharmaceutical initiatives to inhibit cyclin D1 are focused on the catalytic component since the transforming capacity is thought to reside in the cyclin D1/CDK activity. We initiated the following st...