In Islamic law it is necessary for a binding agreement to take place; certain conditions are be satisfied and valid transaction can formed if elements laid down in met order consider lawful. The majority of jurists hold that those essential upon which contract bases itself threefold. formation; Ijab Qabūl (Sighah) subject matter lastly the parties essence validity offer acceptance mutual consen...

Postoperative cognitive dysfunction (POCD), common in elderly patients, refers to a decline in cognitive function following surgery, which may persist or even evolve into Alzheimer's disease (AD). Despite great efforts, the mechanism of POCD remains unclear. In the present study, we tested the hypothesis that Toll-like receptor 4 (TLR4) on microglia contributes to POCD. Shortly after surgery, a...