BACKGROUND Ischemic preconditioning (IPC) of the heart is a protective strategy in which a brief ischemic stimulus immediately before a lethal ischemic episode potently limits infarct size. Although very promising in animal models of myocardial infarction, IPC has not yet been successfully translated to benefit for patients. OBJECTIVE To appraise all preclinical evidence on IPC for myocardial...

PURPOSE: To evaluate the effect of remote ischemic preconditioning (IPC-R) in the fetal small bowel transplantation model. METHODS: Two groups were constituted: The Isogenic transplant (ISO, C57BL/6 mice, n=24) and the allogenic transplant (ALO, BALB/c mice, n=24). In each group, the animals were distributed with and without IPC-R. It was obtained the following subgroups: Tx, IPC-R, Fk, IPC-F...

اواسط شهریور 1401 و در نزدیکی ساحل ماسه‌ای رودخانۀ نکا شمال ایران، به روش تورزدن روی گل‌آذین بوته‌های کاهوک (.Lactuca serriola L) میان تمشک وحشی (.Rubus idaeus انار (.Punica granatum L)، نمونه‌ای جیرجیرک جمع‌آوری شد که بررسی توسط کلیدهای شناسایی شکل‌شناسی مقایسه با نمونه‌های از قبل تعیین نام شدۀ موزۀ حشرات هایک میرزایانس رکورد جدید جنس گونه را تایید کرد. این اولین گزارش گونۀ Arachnocephalus ves...

BACKGROUND Rapid ischemic preconditioning (IPC) has been shown to reduce cellular injury after subsequent cardiac and cerebral ischemia. However, the data on rapid IPC of the spinal cord is limited. The authors investigated whether pretreatment with sublethal ischemia of spinal cord can attenuate neuronal injury after spinal cord ischemia in rabbits. METHODS Forty-seven male New Zealand white...

BACKGROUND Intermittent pneumatic compression (IPC) has been successfully used in the treatment of venous ulcers, although the optimal setting of pressure, inflation and deflation times has not yet been established. The aim of this study was to compare the effect of two different combinations of IPC pump settings (rapid vs slow) in the healing of venous ulcers. MATERIAL/METHODS 104 patients w...

BACKGROUND Here, we determined miR-499 involvement in the protective effect of ischemic postconditioning (IPC) against myocardial ischemia/reperfusion (I/R) injury and identified the underlying mechanisms. METHODS To investigate the cardioprotective effect of IPC-induced miR-499, rats were divided into the following five groups: sham, I/R, IPC, IPC + scramble, and IPC + antagomiR-499. Hemodyn...

PURPOSE To examine the mechanisms of ischemic preconditioning (IPC) related to the opening of mitochondrial KATP (mKATP) channels in the retina. METHODS Rats were subjected to retinal ischemia after IPC, or retinas were rendered ischemic after pharmacological opening of mKATP channels. The effects of blocking mKATP channel opening, nitric oxide synthase (NOS) subtypes, or protein kinase C (PK...

BACKGROUND Ischemic preconditioning (IPC) could protect against subsequent renal ischemia reperfusion injury (IRI). However, the mechanisms underlying IPC remain far from complete. Hence, we explored the effects of IPC on the renal and systemic hemodynamic changes, renal function and morphology, as well the involvement of endothelial and inducible nitric oxide synthase (eNOS/iNOS), and nitric o...

MicroRNAs (miRNAs) are noncoding RNAs of 18 to 24 nucleotides that are involved in posttranscriptional regulation of protein expression. Their role in ischemic preconditioning (IPC) is currently unknown. We hypothesized that miRNAs induced after IPC in the heart may create a preconditioned phenotype through upregulating proteins including endothelial nitric oxide synthase (eNOS)/inducible nitri...

Recent advances in interprocess communication (IPC) performance have been exclusively based on threadmigrating IPC designs. Thread-migrating designs assume that IPC interactions are synchronous, and that user-level execution will usually resume with the invoked process (modulo preemption). This IPC design approach offers shorter instruction path lengths, requires fewer locks, has smaller instru...