The goal of this study was to compare the functions of Clara and type II cells during alveolar clearance and recycling of surfactant protein (SP) A, a secretory product of both cell types. We examined the incorporation of instilled biotinylated SP-A (bSP-A) into rat lung type II and Clara cells as a measure of clearance and recycling of the protein. Ultrastructural localization of bSP-A was acc...

Naphthalene causes severe dose- and site-selective injury to mouse nonciliated bronchiolar (Clara) epithelial cells. Toxicity is characterized by exfoliation of injured Clara cells into the airway lumen 24 h after exposure. The purpose of this study was to define the temporal pattern of intracellular changes immediately following naphthalene treatment, with the goal of identifying critical earl...

Solar surface radiation data of high quality is essential for the appropriate monitoring and analysis of the Earth’s radiation budget and the climate system. Further, they are crucial for the efficient planning and operation of solar energy systems. However, well maintained surface measurements are rare in many regions of the world and over the oceans. There, satellite derived information is th...

We discuss an agency model for an e-market place. When a marketplace goes from brick-and-mortar to virtual, incentive issues of e-mall providers become significant because contracting for an e-mall service can be “outcome-based.” We discuss the internet firm’s incentives associated with the cost of operating an e-mall and different types of optimal contracting policy.  Department of OMIS, Leav...

StochAstic Recursive grAdient algoritHm (SARAH), originally proposed for convex optimization and also proven to be effective general nonconvex optimization, has received great attention because of its simple recursive framework updating stochastic gradient estimates. The performance SARAH significantly depends on the choice step size sequence. However, variants often manually select a best-tune...

Clara cells are non-ciliated, secretory bronchiolar epithelial cells that serve to detoxify harmful inhaled substances. Clara cells also function as stem/progenitor cells for repair in the bronchioles. Clara cell secretory protein (CCSP) is specifically expressed in pulmonary Clara cells and is widely used as a Clara cell marker. In addition CCSP promoter is commonly used to direct gene express...

Various studies indicate that cytodifferentiation of Clara cells and development of pulmonary cytochrome P450 (CYP) monooxygenases occur postnatally. The timing of these events is species-specific. Neonatal mice are more susceptible than adult mice are to Clara cell injury by naphthalene, but little is known about the postnatal development of Clara cells and CYP in mice. This study was designed...