Clara-cell populations show a high degree of variation in susceptibility to injury by bioactivated cytotoxicants. Because glutathione (GSH) is critical for detoxification of electrophilic metabolites, heterogeneity in Clara cell GSH levels may lead to a wide range of cytotoxic responses. This study was designed to define the distinct GSH pools within Clara cells, characterize heterogeneity with...

Previous studies from our laboratory indicated that both beta-adrenergic and cholinergic agents stimulate in vivo secretion by rat bronchiolar Clara cells. Those studies also provided support for an in-series beta-adrenergic-cholinergic stimulation of secretion. To further explore the regulation of secretion in Clara cells, and to do it in the absence of systemic influences, we have used the is...

The 10 kDa Clara cell protein was measured in serum and bronchoalveolar lavage (BAL) from 39 healthy subjects (14 smokers, 25 nonsmokers) and from 41 patients with respiratory disease (chronic obstructive pulmonary disease (COPD), sarcoidosis, lung cancer). Clara cell protein appears as one of the most abundant respiratory tract derived proteins, with values averaging 7% of the total protein co...

Many high mountaineers die of acute mountain sickness in the high mountains of Nepal during their adventure. Most of them administer acetaminophen (AP) as an analgesic. Various cells with higher expression of cytochrome P-450 (CYP) would metabolize AP and lead to cellular impairment. CYP is a major enzyme system in the metabolism of xenobiotics in different organs of the human being including i...

Keith Rayburn, MD, is a physician in the Department of Medicine, Santa Clara Valley Medical Center, San Jose, California. Eric Fleischbein, PharmD, is a pharmacist in the Department of Pharmacy Services, Santa Clara Valley Medical Center. Jessica Song, PharmD, is a pharmacist in the Department of Pharmacy Services, Santa Clara VaUey Medical Center, and an instructor at the University ofthe Paci...

Aims. We present a study of the spectrophotometric properties of dwarf planet Ceres in the visual-to-infrared (VIS-IR) spectral range by means of hyper-spectral images acquired by the VIR imaging spectrometer on board the NASA Dawn mission. Methods. Disk-resolved observations with a phase angle within the 7◦ < α < 132◦ interval were used to characterize Ceres’ phase curve in the 0.465–4.05 μm s...

Context. Astronomical research dealing with accurate radial velocity measurements need reliable astronomical standards to calibrate the spectrographs and to assess possible systematics. Stellar radial velocity standards offer a reference at the level of a few hundred m s−1 and are not adequate for most present needs. Aims. We aim to show that sunlight reflected by asteroids is a fairly accessib...

During 1999 the CERES experiment upgraded by the new TPC was taking data from semi-central Pb+Au collisions at 40 AGeV. The analysis of the di-electron spectra shows an enhancement in the low mass region of at least the same magnitude as previously observed at full SPS energy. The results are compared to model calculations with and without medium modifications of the vector mesons. The addition...

Clara is a novel static-analysis framework for partially evaluating finite-state runtime monitors at compile time. Clara uses static typestate analyses to automatically convert any AspectJ monitoring aspect into a residual runtime monitor that only monitors events triggered by program locations that the analyses failed to prove safe. If the static analysis succeeds on all locations, this gives ...

Stinging Nettle Cream for Osteoarthritis Keith Rayburn, MD, is a physician in the Department of Medicine, Santa Clara Valley Medical Center, San Jose, California. Eric Fleischbein, PharmD, is a pharmacist in the Department of Pharmacy Services, Santa Clara Valley Medical Center. Jessica Song, PharmD, is a pharmacist in the Department of Pharmacy Services, Santa Clara Valley Medical Center, and ...