نتایج جستجو برای: مدل adcc
تعداد نتایج: 121197 فیلتر نتایج به سال:
Previous investigations of mononuclear cell antibody-dependent cell-mediated cytotoxicity (ADCC) toward tumor cells suggest that K lymphocytes and not monocytes are active in this cytotoxic reaction. This report, however, demonstrates that human monocytes are able to carry out ADCC toward three different human tumor cell lines (CEM T lymphoblasts, Raji bone marrow-derived (B) lymphoblasts, and ...
TNFα played a dominant role in the development and progression of rheumatoid arthritis (RA). Clinical trials proved the efficacies of anti-TNFα agents for curing RA. However, most researchers were concentrating on their abilities of neutralizing TNFα, the potencies of different anti-TNFα agents varied a lot due to the antibody-dependent cell-mediated cytotoxicity (ADCC) or complement dependent ...
سابقه و هدف: تومورهای غده بزاقی اخیراً دستخوش تغییر قرار گرفته، انواع جدیدی از آنها شناسایی شدهاند. از این میان دو تومور (AdCC) Adenoid cystic carcinoma و (PLGA) Polymorphous low-grade Adenocarcinoma دارای شباهتهایی هستند که میتوانند سبب اشتباه تشخیصی شوند، به همین دلیل مطالعه حاضر با هدف مقایسه آدنوئید سیستیک کارسینوما و آدنوکارسینوم پلیمورفوس low-grade غدد بزاقی با استفاده صورت پذیرفت.مواد...
Several anti-PD-1/PD-L1 monoclonal antibodies (mAb) are currently providing evidence of clinical benefit in subsets of cancer patients. The mode of action of these mAbs is to inhibit PD-1 on immune cells interacting with PD-L1 on tumor cells. These mAbs are either designed or engineered to eliminate antibody-dependent cell-mediated cytotoxicity (ADCC), which, however, has been implicated as an ...
The central tumoricidal activity of anticancer monoclonal antibodies (mAb) is exerted by FcgR IIIa (CD16)– expressing effector cells in vivo via antibody-dependent cell-mediated cytotoxicity (ADCC), as observed for natural killer (NK) cells. In practice, chemotherapy-induced leukopenia and exhaustion of NK cells resulting from ADCC often hamper the clinical efficacy of cancer treatment. To circ...
Ab-dependent cellular cytotoxicity (ADCC) is usually considered an important mechanism of action for immunotherapy with human IgG1 but not IgG2 Abs. The epidermal growth factor receptor (EGF-R) Ab panitumumab represents the only human IgG2 Ab approved for immunotherapy and inhibition of EGF-R signaling has been described as its principal mechanism of action. In this study, we investigated effec...
T0001 is a recombinant human TNFR-Fc fusion protein mutant; it exhibits higher affinity to TNFα than etanercept and is now being tested in a Phase 1 study in China (ClinicalTrials.gov Identifier: NCT02481180). T0001 can inhibit the binding of soluble TNFα (sTNFα) or membrane-bound TNFα (mTNFα) to TNF receptors. When bound to mTNFα, the Fc-bearing TNFα antagonists have the potential to induce Fc...
Monoclonal antibodies targeting tumors are one of the most important discoveries in field cancer. Although several effective have been developed, a relapse may occur. One their mechanisms action is Antibody Dependent Cell Cytotoxicity (ADCC), by engaging Fc γ receptor CD16 expressing Natural Killer cells, innate lymphoid cells involved cancer immunosurveillance and able to kill tumor cells. A l...
در این مقاله با بهکارگیری نسل جدید مدلهای نوسانپذیری چندمتغیره شامل مدل ADCC، مدل GO-GARCH و مدلهای GARCH مبتنیبر کاپیولا، به تخمین و بررسی عملکرد پوشش ریسک بازار نقد با بازار آتی سکه بهار آزادی، طی دوره زمانی 5/8/1389 تا 31/4/1395، پرداختهایم. نتایج تجربی حاکی از برتری نسبتهای پوشش ریسک بهدست آمده از مدل GO-GARCH در مقایسه با سایر مدلهای رقیب، برای پوشش ریسک نوسانات قیمتهای نقد با آت...
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