Most proteins within living organisms contain glycans. Glycan structures can modulate the biological properties and function of glycoproteins. Developments in glycobiology have revealed a new type of glycosidic linkage to the peptide portion, the O-mannosyl linkage in mammals, although heretofore it had been thought to be specific to yeast. One of the best known O-mannosyl-modified glycoprotein...

Muscle-eye-brain disease (MEB) is an autosomal recessive disease of unknown etiology characterized by severe mental retardation, ocular abnormalities, congenital muscular dystrophy, and a polymicrogyria-pachygyria-type neuronal migration disorder of the brain. A similar combination of muscle and brain involvement is also seen in Walker-Warburg syndrome (WWS) and Fukuyama congenital muscular dys...

Mixed-population (heterogeneous) enterococcal bacteremia (MEB) is rarely reported. Based on one occasion in which Vitek2 missed a vancomycin-resistant subpopulation isolated from a patient, we developed a simple method to detect this subpopulation and determined MEB frequency. The four patients presented here had either Enterococcus faecium or Enterococcus faecalis bacteremia caused by both van...

The Gutman index (also known as Schultz index of the second kind) of a graph G is defined as Gut(G) = ∑ u,v∈V (G) d(u)d(v)d(u, v). We show that among all graphs on n vertices, the star graph Sn has minimal Gutman index. In addition, we present upper and lower bounds on Gutman index for graphs with minimal and graphs with maximal Gutman index. Corresponding author Supported by project 1M0545 of ...

We address the problem of Minimum Enclosing Ball (MEB) and its generalization to Minimum Enclosing Convex Polytope (MECP). Given n points in a d dimensional Euclidean space, we give a O(nd/ √ ) algorithm for producing an enclosing ball whose radius is at most away from the optimum. In the case of MECP our algorithm takes O(1/ ) iterations to converge. In both cases we improve the existing resul...

A sterically demanding iminophosphonamine ligand [(2,6-iPr2C6H3N)P(Ph2)(NtBu)]H (LH) and its lithium derivative [(2,6-iPr2C6H3N)P(Ph2)(NtBu)](Li·2THF) (1) were used to prepare complexes of group 13 elements. The reaction of LH with AlH3·NMe2Et and AlMe3 respectively, affords [LAlH2]2 (2) and LAlMe2 (3). The lithium derivative 1 when treated with the MCl3 compound of group 13 yields [(2,6-iPr2C6...

این پژوهش با الهام گرفتن از نتایج یک طرح مطالعاتی کاربردی، رویکرد سلسله­‌مراتبی جهت پیگیری فرایند توسعه تأمین‌کنندگان و حمایت تصمیمات موجود در هر مراحل آن ارائه‌ می‌کند. ابتدا، زمینه‌های تأمین نیازمند سپس واجد شرایط هریک زمینه‌ها به کمک تصمیم‌گیری چندشاخصه بهترین-بدترین مشخص می‌گردند. معیارهای شناسایی نیز مرور مطالعات پیشین بهره‌گیری نظرات خبرگان حوزه‌ی خرید استخراج‌شده‌اند. درنهایت، مدل ریاضی ...

An Escherichia coli strain capable of producing the potent antibiotic erythromycin C (Ery C) was developed by expressing 17 new heterologous genes in a 6-deoxyerythronolide B (6dEB) producer strain. The megalomicin gene cluster was used as the source for the construction of two artificial operons that contained the genes encoding the deoxysugar biosynthetic and tailoring enzymes necessary to co...

Training a Support Vector Machine (SVM) requires the solution of a quadratic programming problem (QP) whose computational complexity becomes prohibitively expensive for large scale datasets. Traditional optimization methods cannot be directly applied in these cases, mainly due to memory restrictions. By adopting a slightly different objective function and under mild conditions on the kernel use...

Sarah Maheux-Lacroix MD-PhD candidate ([email protected]) Amélie Boutin MSc ([email protected]) Lynne Moore PhD ([email protected]) Marie-Ève Bergeron MD ([email protected]) Emmanuel Bujold MD-MSc ([email protected]) Philippe Y. Laberge MD ([email protected]) Madeleine Lemyre MD ([email protected]) Sylvie Dodin MD-...