The gene networks underlying closure of the optic fissure during vertebrate eye development are poorly understood. We used a novel clustering method based on Laplacian Eigenmaps, a nonlinear dimension reduction method, to analyze microarray data from laser capture microdissected (LCM) cells at the site and developmental stages (days 10.5 to 12.5) of optic fissure closure. Our new method provide...

INTRODUCTION There is very limited literature describing the association of lateral condyle mass (LCM) fracture of the distal humerus associated concurrently with olecranon fracture. Herein, a case is reported of a displaced LCM fracture with displaced olecranon fracture, due to complex trauma while getting out of a vehicle, which was managed by open reduction and internal fixation. CASE PRES...

We study the sequences generated by neuronal recurrence equations of the form x(n) = 1[ ∑h j=1 ajx(n − j) − θ]. From a neuronal recurrence equation of memory size h which describes a cycle of length ρ(m)× lcm(p0, p1, . . . , p−1+ρ(m)), we construct a set of ρ(m) neuronal recurrence equations whose dynamics describe respectively the transient of length O(ρ(m)×lcm(p0, . . . , pd)) and the cycle o...

This paper established how LAN Chat Messenger (LCM) using Rational Unified Process (RUP) methodology provides low-cost communication between staff in an organization. In the process, it enables users to make voice calls, chat and transfer of small to medium-sized files. The paper provides information about how voice calls are made, call history is shown, chat conversations are saved and quick f...

We present two new algorithms, LCM and IBFS, that make locally optimal incre-mental planning decisions for the task of nding a path to a goal state in a problem space that contains cycles. Earlier work (RTA* 10]) only solves this locally optimal decision problem when the problem space is tree structured. We precisely characterize the time and space complexity of both new algorithms, and show th...

Infection of H-2-identical mice with either lymphocytic choriomeningitis (LCM) virus, vaccinia virus, or paramyxo (Sendai) virus resulted in the generation of specifically sensitized cytotoxic T lymphocytes (CTL). CTL generated in vitro against 2,4,6-trinitrophenyl (TNP)-conjugated syngeneic stimulator cells were specifically cytotoxic for TNP-conjugated H-2K (D) region identical targets. Both ...

Infection of CBA/J mice with low doses of strain WE lymphocytic choriomeningitis (LCM) virus resulted in high cell-mediated and relatively low humoral virus-specific immune phenomena; anamnestic responses were marked. In contrast, infection with high doses of this virus induced no or low degrees of cell-mediated immune phenomena but higher antibody concentrations. Subsequent challenge of these ...

The HER2/neu oncogene has been reported to be amplified in > 20% of invasive ductal carcinomas. In order to investigate the HER2/neu status in pure populations of breast cancer cells, a laser capture microdissection (LCM) system was used. Formalin-fixed paraffin-embedded breast tissue areas corresponding to normal ducts, ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) were m...