OBJECTIVE To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP). METHODS Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and at 24 hours, 72 hours, and 7 days after SRC. A sample of 21 nonathlete controls were compared at...

In this paper, we introduce the notions of expansion of ideals in $MV$-algebras, $ (tau,sigma)- $primary, $ (tau,sigma)$-obstinate  and $ (tau,sigma)$-Boolean  in $ MV- $algebras. We investigate the relations of them. For example, we show that every $ (tau,sigma)$-obstinate ideal of an $ MV-$ algebra is $ (tau,sigma)$-primary  and $ (tau,sigma)$-Boolean. In particular, we define an expansion $ ...

Background Alzheimer’s Disease, the leading cause of dementia, is over-represented in females. The apolipoprotein E (APOE) ε4 allele strongest genetic risk factor for late-onset AD and associated with aberrant cerebrospinal fluid levels (CSF) total tau (t-tau), phosphorylated (p-tau), amyloid-β (Aβ). There some evidence that sex may mediate relationship between APOE status CSF tau, however, mix...

Converging evidence suggests that psychotic Alzheimer's disease (AD + P) is associated with an acceleration of frontal degeneration, with tau pathology playing a primary role. Previous histopathologic and biomarker studies have specifically implicated tau pathology in this condition. To precisely quantify tau abnormalities in the frontal cortex in AD + P, we used a sensitive biochemical assay o...

INTRODUCTION Recent literature proposes that amyloid β (Aβ) and phosphorylated tau (p-tau) synergism accelerates biomarker abnormalities in controls. Yet, it remains to be answered whether this synergism is the driving force behind Alzheimer disease (AD) dementia. METHODS We stratified 314 mild cognitive impairment individuals using [18F]florbetapir positron emission tomography Aβ imaging and...

We previously reported that, in the brains of older patients with vascular dementia (VaD), there is a distinctive accumulation of detergent-extractable soluble amyloid-β, with a predominance of Aβ42 species. It is unclear, however, if tau proteins also accumulate in the brains of older VaD subjects. Using antibody-specific immunoassays, we assessed concentrations of total tau (t-tau) and phosph...

The genetic mechanisms that regulate neurodegeneration are only poorly understood. We show that the loss of one allele of the p53 family member, p73, makes mice susceptible to neurodegeneration as a consequence of aging or Alzheimer's disease (AD). Behavioral analyses demonstrated that old, but not young, p73+/- mice displayed reduced motor and cognitive function, CNS atrophy, and neuronal dege...

INTRODUCTION Deposition of abnormally phosphorylated tau (phospho-tau) occurs in Alzheimer's disease but also with brain ageing. The Braak staging scheme focused on neurofibrillary tangles, but abundant p-tau is also present in neuropil threads, and a recent scheme has been proposed by the BrainNet Europe consortium for staging tau pathology based on neuropil threads. We determined the relation...

According to recent studies, the determination of cerebrospinal fluid (CSF) total tau (t-tau)/phosphorylated tau (p-tau) ratio and total prion protein (t-PrP) levels significantly improves the accuracy of the diagnosis of Alzheimer's disease (AD) in atypical cases with clinical or laboratory features mimicking Creutzfeldt-Jakob disease (CJD). However, this has neither been validated nor tested ...