Objectives: This longitudinal study aims at 1) providing preliminary evidence of changes in blood-based biomarkers across time chronic TBI and 2) relating these to outcome measures cerebral structure activity.Methods: Eight patients with moderate-to-severe (7 males, 35 ± 7.6 years old, 5 severe TBI, 17.52 3.84 months post-injury) were evaluated monthly intervals 6 time-points using: a) Blood-ba...

In 2013, Masson and Siljander determined a method to prove that the minimal p-weak upper gradient $$g_{f_\varepsilon }$$ for time mollification $$f_\varepsilon $$ , $$\varepsilon >0$$ of parabolic Newton–Sobolev function $$f\in L^p_\mathrm {loc}(0,\tau ;N^{1,p}_\mathrm {loc}(\Omega ))$$ with $$\tau $$\Omega open domain in doubling metric measure space $$(\mathbb {X},d,\mu )$$ supporting weak (1...

The challenges for establishing an early diagnosis of Alzheimer’s disease (AD) have created a need for biomarkers that reflect the core pathology of the disease. The cerebrospinal fluid (CSF) levels of total Tau (T-tau), phosphorylated Tau (P-Tau) and beta-amyloid peptide (Ab42) reflect, respectively, neurofibrillary tangle and amyloid pathologies and are considered as surrogate markers of AD p...

OBJECTIVES Cognitive impairment is prevalent in older schizophrenia patients but its biological basis is unknown. Neuropathological studies have not revealed Alzheimer disease (AD) lesion burden but in vivo data are lacking. METHOD We investigated the concentrations of CSF biomarkers of brain amyloidosis (Abeta42) and neurodegeneration (total and p-tau) in a group of older schizophrenia patie...

This p&per outlines the pqtential for new particle searches in tau and charm physics at a Tau-Charm Factory.

BACKGROUND Autism is associated with impairments that have life-time consequences for diagnosed individuals and a substantial impact on families. There is growing interest in early interventions for children with autism, yet despite the substantial economic burden, there is little evidence of the cost-effectiveness of such interventions with which to support resource allocation decisions. This ...

Objectives: To assess associations between cerebrospinal fluid (CSF) biomarker levels and MRI-based whole-brain atrophy rate in mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Methods: We included 99 patients (47 AD, 29 MCI, 23 controls) who underwent lumbar puncture at baseline and repeat MRI. A subgroup of 48 patients underwent a second lumbar puncture. CSF levels of beta-amyloi...

ence of two aberrant histopathological structures: the senile plaques and the neurofibrillary tangles. In the decade of the 1980s it was described that A peptide is the major component of senile plaques [1]. Also, in the same decade, the pioneer works of GrundkeIqbal et al. described the presence of tau [2], in hyperphosphorylated form [3], in the neurofibrillary tangles. Thus, two main feature...

AIM To investigate a possible correlation between the histological and morphometric properties of herniated intervertebral disc, clinical and magnetic resonance imaging (MRI) characteristics of patients with lumbar disc degeneration (LDD). MATERIALS AND METHODS Thirty six patients with LDD were clinically evaluated using Japanese Orthopaedic Association Score (JOAS), visual analogue scale (VA...

‎let $r$ be a $*$-prime ring with center‎ ‎$z(r)$‎, ‎$d$ a non-zero $(sigma,tau)$-derivation of $r$ with associated‎ ‎automorphisms $sigma$ and $tau$ of $r$‎, ‎such that $sigma$‎, ‎$tau$‎ ‎and $d$ commute with $'*'$‎. ‎suppose that $u$ is an ideal of $r$ such that $u^*=u$‎, ‎and $c_{sigma,tau}={cin‎ ‎r~|~csigma(x)=tau(x)c~mbox{for~all}~xin r}.$ in the present paper‎, ‎it is shown that...