In Hyderabad there is a big center for automatic translation. There, a battery of computers day and night reads through a mass of newspapers, magazines, books, and reports from all over the world. Mostly by internet, sometimes by scanning of paper archives. These indefatigable computers don’t do that just for fun. Their human masters trained them to do this endless reading. Actually the trainin...

The emergence of distributed ledger technology (DLT) based upon a blockchain data structure, has given rise to new approaches to identity management that aim to upend dominant approaches to providing and consuming digital identities. These new approaches to identity management (IdM) propose to enhance decentralisation, transparency and user control in transactions that involve identity informat...

This document provides the statistical background for the Bayesian model averaging continual reassessment method (BMA-CRM). The BMA-CRM is a Bayesian model-based phase I clinical trial design. The primary goal of the BMA-CRM is to identify the maximum tolerated dose (MTD) of a new drug, which is typically defined as the dose with a doselimiting toxicity (DLT) probability that is closest to the ...

A 54-year-old man with polycystic liver disease received a domino liver transplantation (DLT) from a patient of hereditary ATTR amyloidosis with the transthyretin Ser50Arg mutation. Ten years after transplantation, he felt a slight numbness in his toes, and cardiac amyloidosis was simultaneously suspected upon a heart function evaluation. Biopsy specimens from the myocardium revealed transthyre...

Double lumen tubes (DLT) are a cornerstone in thoracic anaesthesia to achieve onelung ventilation. Due to the shape and size of these devices, airway injuries might occur. The reported incidence of tracheobronchial ruptures caused by a DLT is very low (0.005% for single-lumen tubes and 0.05% for double-lumen intubations), but the outcome can be life-threatening (1, 2). In the past, treatment of...

Blockchain and distributed ledger technologies (DLT) are emerging decentralized infrastructures touted by researchers to improve existing systems that have been limited centralized governance proprietary control. These shown continued success in sustaining the operational models of modern cryptocurrencies finance applications (DeFi). has incentivized growing discussions their potential adoption...

Abstract The breakthrough of Distributed Ledger Technologies (DLT) has enabled the emergence and implementation a wide range digital platforms in Virtual Enterprises (VE) which collaborate to provide services. DLT potential revolutionize VE by offering transparent, decentralized, trustworthy, data provenance, reliable, auditable features. Yet, full deployment systems is still limited since some...

Distributed Ledger Technologies (DLT) promise to revolutionize business ecosystems by permitting secure transactions without intermediaries. A widely recognized challenge that inhibits the uptake of DLT is scalability and performance. Hence, quantifying key metrics such as throughput latency crucial for designing DLT-based infrastructures, applications, ecosystems. However, current benchmarking...

Epidemiologic data support an inverse association between green tea intake and breast cancer risk, and numerous experimental studies have shown the antitumor effects of its main component, epigallocatechin gallate (EGCG). We conducted a phase IB dose escalation trial in women with a history of stage I to III hormone receptor-negative breast cancer of an oral green tea extract, polyphenon E (Pol...