PURPOSE A phase I study to define toxicity and recommend a phase II dose of the HSP90 inhibitor alvespimycin (17-DMAG; 17-dimethylaminoethylamino-17-demethoxygeldanamycin). Secondary endpoints included evaluation of pharmacokinetic profile, tumor response, and definition of a biologically effective dose (BED). PATIENTS AND METHODS Patients with advanced solid cancers were treated with weekly,...

Abstract Nations worldwide have sought to capitalize on the benefits of distributed ledger technology (DLT) including Blockchain, but struggled strike a balance between encouraging investment and innovation in while addressing challenges uncertainties through regulation. Through its FinTech (Financial Technology) Strategy, Qatar has embrace DLT, regulatory approach also remains cautious. Trade ...

Jambi University has a fostered village called the Integrated Laboratory Village (DLT). The DLT program is directed at developing villages as centers of economic activity that are independent and technologically minded. Thus, it necessary to design MBKM activities carried out by in so they line with goals objectives DLT. This study aims develop an learning model (MB) targeting rural communities...

PURPOSE This first-in-human dose-escalating trial investigated the safety, tolerability, maximum tolerated dose (MTD), dose-limiting toxicities (DLT), pharmacokinetics, and pharmacodynamics of the novel histone deacetylase (HDAC) inhibitor resminostat in patients with advanced solid tumors. EXPERIMENTAL DESIGN Resminostat was administered orally once-daily on days 1 to 5 every 14 days at 5 do...

PURPOSE To assess the maximum tolerated dose (MTD)/dose-limiting toxicities (DLT), safety, pharmacokinetics, and pharmacodynamics of tivozanib, a potent and selective oral VEGF receptor (VEGFR) tyrosine kinase inhibitor. EXPERIMENTAL DESIGN Dose levels of 1.0, 1.5, and 2.0 mg/d tivozanib for 28 days followed by 14 days of medication were explored in patients with advanced solid tumors. RESU...

The rate of observed dose-limiting toxicities (DLT) determines the maximum tolerated dose (MTD) in phase I trials. There are cases in which non-drug-related toxicities or other-cause toxicities (OCT) are flagged as DLTs, or vice versa, due to attribution errors. We aim to assess the impact of such errors on the final estimate of MTD. We compared the impact of attribution errors using 2 trial de...

Current formal models of real-time workloads were designed within the context of uniprocessor real-time systems; hence, they are often not able to accurately represent salient features of multiprocessor real-time systems. Researchers have recently attempted to overcome this shortcoming by applying workload models from Divisible Load Theory (DLT) to real-time systems. The resulting theory, refer...

Communication between vehicles and their environment (i.e., vehicle-to-everything or V2X communication) in vehicular ad hoc networks (VANETs) has become of particular importance for smart cities. However, economic challenges, such as the cost incurred by data sharing (e.g., due to power consumption), hinder integration open systems into city applications, dynamic environmental zones. Moving fro...

With the faster maturity and stability of digitization, connectivity edge technologies, number Internet Things (IoT) devices sensors is flourishing fast in important junctions such as homes, hotels, hospitals, retail stores, manufacturing floors, railway stations, airports, oil wells, warehouses, etc. However, this extremely connected world, security implications for IoT are getting worse with ...