OBJECTIVE To understand how aquaporin4 (AQP4) and dystroglycan (DG) polarized distribution change and their roles in brain edema formation after traumatic brain injury (TBI). METHODS Brain water content, Evans blue detection, real-time PCR, western blot, and immunofluorescence were used. RESULTS At an early stage of TBI, AQP4 and DG maintained vessel-like pattern in perivascular endfeet; M1...

Disordered gambling (DG) will soon be included along with the substance use disorders in a revised diagnostic category of the Diagnostic and Statistical Manual of Mental Disorders DSM-5 called 'Substance Use and Addictive Disorders'. This was premised in part on the common etiologies of DG and the substance use disorders. Using data from the national community-based Australian Twin Registry, we...

The steady-state brain/plasma distribution ratios of [14C]deoxyglucose ([14C]DG) for hypoglycemic rats previously determined by measurement of DG concentrations in neutralized acid extracts of freeze-blown brain and plasma exceeded those predicted by simulations of kinetics of the DG model. Overestimation of the true size of the precursor pool of [14C]DG for transport and phosphorylation could ...

PURPOSE The aim of this study was to evaluate 99mTc-ethylenedicysteine-glucosamine (EC-DG) for the assessment of tumor growth. METHOD To evaluate whether 99mTc-EC-DG is involved in cell nuclei activity, in vitro thymidine incorporation, and cell-cycle assays of EC-DG were conducted using lung and breast cancer cells. Biodistribution of 99mTc-EC-DG in lung tumor-bearing mice (0.5-4 hours, 1 Ci...

2-Deoxyglucose (2-DG) is a toxic glucose analog. To identify genes involved in 2-DG toxicity in Schizosaccharomyces pombe, we screened a wild-type overexpression library for genes which render cells 2-DG resistant. A gene we termed odr1, encoding an uncharacterized hydrolase, led to strong resistance and altered invertase expression when overexpressed. We speculate that Odr1 neutralizes the tox...

The success of transplants of neural tissue into the adult dentate gyrus in generating mature neurons is highly variable. Here we address the roles of the origin of the tissue and its pre-implantation preparation, and show that both are critical. We transplanted neonatal cultured or primary rat cells from either the ventral subventricular zone (vSVZ) or the dentate gyrus (DG) into the adult rat...

The Balaban index of a connected graph G is defined as J(G) = |E(G)| μ+ 1 ∑ e=uv∈E(G) 1 √ DG(u)DG(v) , and the Sum-Balaban index is defined as SJ(G) = |E(G)| μ+ 1 ∑ e=uv∈E(G) 1 √ DG(u)+DG(v) , where DG(u) = ∑ w∈V (G) dG(u,w), and μ is the cyclomatic number of G. In this paper, the unicyclic graphs with the maximum Balaban index and the maximum Sum-Balaban index among all unicyclic graphs on n v...

Consider a field k of characteristic p > 0, G(r) the r-th Frobenius kernel of a smooth algebraic group G, DG(r) the Drinfeld double of G(r), and M a finite dimensional DG(r)-module. We prove that the cohomology algebra H(DG(r), k) is finitely generated and that H(DG(r),M) is a finitely generated module over this cohomology algebra. We exhibit a finite map of algebras θr : H(G(r), k) ⊗ S(g) → H(...

Distributed generators are very much beneficial in reducing the losses effectively compared to other methods of loss reduction .In this paper optimal size of DG unit operated at optimal power factor is dealt. DG unit placement using fuzzy logic and sizing of DG at any power factor is calculated using analytical method . Voltage and power loss reduction indices of distribution system nodes are m...

Measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) has recently become more popular as a means of assessing oxidative stress in the human body. Although using high-performance liquid chromatography with electrochemical detection (HPLC-ECD) is a reliable method of measuring 8-oxo-dG, easier and simpler alternative methods may be preferred, if they are quantitatively accurate. ...