The Rockefeller University Press $30.00 J. Cell Biol. Vol. 207 No. 2 299–315 www.jcb.org/cgi/doi/10.1083/jcb.201404067 JCB 299 Correspondence to James E. Bear: [email protected] Abbreviations used in this paper: 4-OHT, 4-hydroxy-tamoxifen; AMPK, AMPactivated protein kinase; ANOVA, analysis of variance; BRSK, brain-specific kinase; DN, dominant negative; FMI, forward migration index; MARK, mic...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 208 No. 5 563–579 www.jcb.org/cgi/doi/10.1083/jcb.201406099 JCB 563 *R. Zellweger and D. Dalcher contributed equally to this paper. Correspondence to Massimo Lopes: Massimo Lopes [email protected] Abbreviation used in this paper: ANOVA, analysis of variance; APH, aphidicolin; CDDP, cis-diamminedichloroplatinum; CldU, chlorodeoxyuridine;...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 205 No. 2 179–195 www.jcb.org/cgi/doi/10.1083/jcb.201312066 JCB 179 Correspondence to György Hajnóczky: [email protected] Abbreviations used in this paper: 2P, two photon; ADOA, autosomal-dominant optical atrophy; CRU, Ca2+ release unit; CSMDH, Ca2+-sensitive mitochondrial matrix dehydrogenase; EC, excitation–contraction; E...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 206 No. 2 289–305 www.jcb.org/cgi/doi/10.1083/jcb.201404118 JCB 289 M. Rahman, N.K. Nirala, and A. Singh contributed equally to this paper. Correspondence to Usha R. Acharya: [email protected] Abbreviations used in this paper: BN, blue native; GO, gene ontology; LC, liquid chromatography; OXPHOS, oxidative phosphorylation; ROS, ...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 204 No. 4 541–557 www.jcb.org/cgi/doi/10.1083/jcb.201307050 JCB 541 Correspondence to Taras Y. Nazarko: [email protected]; or Suresh Subramani: [email protected] Abbreviations used in this paper: 30BS, Atg30 binding site; ACBD5, acylCoA–binding domain containing protein 5; ACBS, acyl-CoA binding site; AD, Alzheimer’s disease; AIM, Atg...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 208 No. 1 53–69 www.jcb.org/cgi/doi/10.1083/jcb.201404109 JCB 53 Correspondence to Rabindranath De La Fuente: [email protected]; or John C. Schimenti: [email protected] Abbreviations used in this paper: ACT, activator of CREM in testis; CREM, cAMP response element modulator; GV, germinal vesicle; IAP, intracisternal A particle; MGI, Mouse...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 208 No. 4 475–491 www.jcb.org/cgi/doi/10.1083/jcb.201406121 JCB 475 *W.A. Comrie and A. Babich contributed equally to this paper. Correspondence to Janis K. Burkhardt: [email protected] Abbreviations used in this paper: APC, antigen-presenting cell; Bleb, blebbistatin; cSMAC, central supramolecular activation cluster; dSMAC, d...

Multiple system atrophy is a sporadic alpha-synucleinopathy that typically affects patients in their sixth decade of life and beyond. The defining clinical features of the disease include progressive autonomic failure, parkinsonism, and cerebellar ataxia leading to significant disability. Pathologically, multiple system atrophy is characterized by glial cytoplasmic inclusions containing filamen...

Mutations in the gene superoxide dismutase 1 (SOD1) are causative for familial forms of the neurodegenerative disease amyotrophic lateral sclerosis. When the first SOD1 mutations were identified they were postulated to give rise to amyotrophic lateral sclerosis through a loss of function mechanism, but experimental data soon showed that the disease arises from a—still unknown—toxic gain of func...

Improving neurological outcome after spinal cord injury is a major clinical challenge because axons, once severed, do not regenerate but ‘dieback’ from the lesion site. Although microglia, the immunocompetent cells of the brain and spinal cord respond rapidly to spinal cord injury, their role in subsequent injury or repair remains unclear. To assess the role of microglia in spinal cord white ma...