OBJECTIVE HbA1c is associated with cardiovascular risk in persons without diabetes and cardiovascular risk accumulates over the life course. Therefore, insight in factors determining HbA1c from childhood onwards is important. We investigated (lifestyle) determinants of HbA1c at age 12 years and the effects of growth on change in HbA1c and the tracking of HbA1c between the age of 8 and 12 years....

We conducted a six-month randomized-controlled-trial to evaluate the effectiveness of a colour-coded HbA1c-graphical record in improving HbA1c level among type 2 diabetes patients. There was an improvement in the mean HbA1c knowledge score but the usage of the colour-coded HbA1c-graphical record did not produce reduction in the HbA1c level.

AIM The updated mean HbA1c has been used in risk estimates of diabetic complications, but it does not take into account the temporal relationship between HbA1c and diabetic complications. We studied whether the updated mean HbA1c underestimated the risk of diabetic complications. METHOD Continuous HbA1c curves for 10,000 hypothetical diabetes patients were simulated over an average of 7 years...

OBJECTIVE The primary objective was to assess associations between increases in glycated hemoglobin (HbA1c) levels and medication adjustments among patients with diabetes. A secondary objective was to measure the effect of adjustments on subsequent HbA1c levels. METHODS A retrospective analysis of administrative data from a large health insurer in Hawaii of 7654 patients with diabetes mellitu...

BACKGROUND There is limited evidence that among HIV-infected patients haemoglobin A1c (HbA1c) values may not accurately reflect glycaemia. We assessed HbA1c discordance (observed HbA1c - expected HbA1c) and associated factors among HIV-infected participants in the Multicenter AIDS Cohort Study (MACS). METHODS Fasting glucose (FG) and HbA1c were measured at each semi-annual MACS visit since 19...

INTRODUCTION This subgroup analysis of data from the 16-week Lantus Registry Study in China investigated the characteristics of patients with type 2 diabetes mellitus (T2DM) associated with clinical benefits of transitioning therapy from premixed insulin to insulin glargine (100 U/ml) plus oral antidiabetic drugs (OADs). METHODS The modified intention-to-treat population of the Lantus Registr...

OBJECTIVE To study the relationships of long-term trajectories of glycemic control with cognitive performance in cognitively normal elderly with type 2 diabetes (T2D). METHODS Subjects (n = 835) pertain to a diabetes registry (DR) established in 1998 with an average of 18 HbA1c measurements per subject, permitting identification of distinctive trajectory groups of HbA1c and examining their as...

OBJECTIVE HbA1c measurements are typically less variable than fasting plasma glucose (FPG) for diagnosing diabetes, and for assessment of progress on glucose control therapy. However HbA1c reaches steady-state relative to average plasma glucose over about 120 days. HbA1c thus overestimates average FPG during first three months of starting therapy in newly diagnosed diabetic patients, and care n...