Escherichia coli ribosomal protein L3 stimulates the in vitro helicase activity of Bacillus stearothermophilus PcrA helicase upon a variety of different substrates. L3 has no intrinsic helicase or ATPase activity nor is it able to stimulate the ATPase activity of PcrA. Gel mobility shift assays revealed that the affinity of PcrA for a variety of different DNA species (single-stranded, nicked an...

Colon cancer is one of the leading causes of cancer-related death worldwide and the therapy with 5-fluorouracil (5-FU) is mainly limited due to resistance. Recently, we have demonstrated that nucleolar stress upon 5-FU treatment leads to the activation of ribosome-free rpL3 (L3) as proapoptotic factor. In this study, we analyzed L3 expression profile in colon cancer tissues and demonstrated tha...

Triazoles are known for their non-toxicity, higher stability and therapeutic activity. Few nucleoside (L1, L2 and L3) and non-nucleoside 1,2,3-triazoles (L4-L14) were synthesised using click chemistry and they were screened for tumor cell cytotoxicity and proliferation. Among these triazole ligands studied, nucleoside ligands exhibited higher potential than non-nucleoside ligands. The nucleosid...

Learning a new L2/L3 will undoubtedly be affected by the L1/L2 knowledge of the language learners. The present study examined the lexical interplay among L1, L2 and L3. Two different types of L3 (German and Japanese) were used to evaluate how the bilingual learners’ knowledge of L1 (Chinese) and L2 (English) would impact on the learning of L3 in terms of their different types of lexical relatio...

Reactions of 0.5 eq. of the dinuclear complexes [(g-arene)Ru(l-Cl)Cl]2 (arene = g-C6H6, g-p-PrC6H4Me) and [(Cp*)M(l-Cl)Cl]2 (M = Rh, Ir; Cp* = g-C5Me5) with 4,6-disubstituted pyrazolyl-pyrimidine ligands (L) viz. 4,6-bis(pyrazolyl)pyrimidine (L1), 4,6-bis(3-methyl-pyrazolyl)pyrimidine (L2), 4,6-bis(3,5dimethyl-pyrazolyl)pyrimidine (L3) lead to the formation of the cationic mononuclear complexes...

The cadaver spine motion segment behavior under torsional load was evaluated with the disc intact, with partial anterior discectomy and with spacer insertion. The results of this study explain how anterior lumbar discectomy and interbody fusion (ALIF) affects the torsional stability of the motion segment. The pseudarthrosis rate of the anterior lumbar discectomy and interbody fusion (ALIF)...

In vitro chemotactic responses of infective third-stage larvae (L3) of Brugia pahangi to NaCl, Na2HPO4, KCl, K2HPO4, MgCl2 and CaCl2 were assessed. Compared to deionized water as a control, 200 mm NaCl and 100 mm Na2HPO4 significantly attracted L3 (P < 0.01 and P < 0.01), whereas L3 were likely to avoid 200 mm KCl and 100 mm K2HPO4 (P < 0.05 and P < 0.05). L3 showed no significant tendency to a...