Providing reasoning in GIS domains is a demanding task due to the size of the data that are stored in secondary memory. This is also the case for query answering over spatio-thematic ontologies which act as an interface to the GIS data and filter unintended models. Solving this problem by compiling the ontology into an SQL query works only in those cases in which such a compilation, first-order...

10.1128/MCB.24.14.6253-6267.2004. 2004, 24(14):6253. DOI: Mol. Cell. Biol. Pascal Maire Petrof, Dominique Daegelen, Jean-Paul Concordet and Kiyoshi Kawakami, Pin-Xian Xu, Robert Kelly, Basil J. Lopez, Josiane Demignon, Jacques-Emmanuel Guidotti, Raphaelle Grifone, Christine Laclef, François Spitz, Soledad Phenotype into the Fast-Twitch Phenotype Adult Muscle from the Slow-Twitch Six1 and Eya1 E...

Open-angle glaucoma (glaucoma) is a major eye disorder characterized by optic disc pathology. Recent genome-wide association studies identified new loci associated with clinically relevant optic disc parameters, such as the optic disc area and vertical cup-disc ratio (VCDR). We examined to what extent these loci are involved in glaucoma. The loci studied include ATOH7, CDC7/TGFBR3 and SALL1 for...

The overexpression of eyes absent (Eya) 2 has been found in several human cancers. However, its biological roles and clinical significance in human astrocytoma have not yet been explored. This study investigated the clinical significance and biological roles of Eya2 in human astrocytoma tissues and cell lines. Using immunohistochemistry, we found Eya2 overexpression in 33 out of 90 (36.7%) astr...

PURPOSE Lung adenocarcinoma often manifests as tumors with mainly lepidic growth. The size of invasive foci determines a diagnosis of in situ, minimally invasive adenocarcinoma, or invasive types and suggests that some adenocarcinomas undergo malignant progression in that order. This study investigates how transcriptional aberrations in adenocarcinoma cells at the early stage define the clinica...

PURPOSE The size of the optic nerve head, referred to as disc area (DA), and the vertical cup-disc ratio (VCDR), are clinically relevant parameters for glaucomatous optic neuropathy. Although these measures have a high heritability, little is known about the underlying genes. Previously, the genes SALL1 and SIX1 were found to be genome-wide significantly associated with DA and VCDR. The purpose...

Sineoculis homeobox homolog (SIX) family proteins, including SIX1, SIX2, SIX3, SIX4, SIX5, and SIX6, have been implicated in the initiation and progression of breast cancer, but the role of each member in breast tumor is not fully understood. We conducted a systematic review and meta-analysis to evaluate the association between the mRNA levels of all 6 members and clinic-pathological characteri...

The mood stabilizing agents lithium chloride (LiCl) and sodium valproate (VPA) have recently gained interest as potential neuroprotective therapeutics. However, exploitation of these therapeutic applications is hindered by both a lack of molecular understanding of the mode of action, and a number of sub-optimal properties, including a relatively small therapeutic window and variable patient res...

First-Order Logic (FOL) is widely regarded as one of the most important foundations for knowledge representation. Nevertheless, in this paper, we argue that FOL has several critical issues for this purpose. Instead, we propose an alternative called assertional logic, in which all syntactic objects are categorized as set theoretic constructs including individuals, concepts and operators, and all...

An FOL-program consists of a background theory in a decidable fragment of first-order logic and a collection of rules possibly containing first-order formulas. The formalism stems from recent approaches to tight integrations of ASP with description logics. In this paper, we define a well-founded semantics for FOL-programs based on a new notion of unfounded sets on consistent as well as inconsis...