The effect of coenzyme Q10 on oxidative stress parameters and testicular tissue damage in rats following monosodium glutamate induced excitatory intoxication

Ethanol is a principle ingredient of alcoholic beverages with potential neuronal-genotoxicity, and associated neuronal oxidative DNA damage, neurodegeneration in the CNS and neurocognitive deficits is well documented. Chronic consumption of alcohol is associated with disturbances of mnemonic functions and behavioural deficit. DNA-damaging molecules such as reactive oxygen species (ROS), lipidpe...

Aim: To evaluate the efficacy of an antioxidant herbomineral formulation, Addyzoa (Charak Pharma Pvt. Ltd., Mumbai, India) in oligospermia in comparison with Ubiquinone (Coenzyme Q10). Methods: A double-blind, randomised controlled trial was conducted at Dr Vaze’s clinic, Mumbai. A total of sixty patients, 30 in each group, were studied. Cap Addyzoa was administered in a dose of two capsules tw...

The thermal dependence of locomotor performance and in vitro muscle mechanical properties were studied after acclimation at 10 degrees and 20 degrees C in the salamander Ambystoma tigrinum nebulosum Hallowell. Performance measurements included burst and endurance capacities on land and in water. No significant differences in locomotor performance or muscle contractile properties were found betw...

Adriamycin inhibits the succinoxidase system and the NADH-oxidase system. Both of the intact mitocondrial enzymes and the pentane-extracted preparations are inhibited. The inhibition can be prevented by a molar ratio of coenzyme to adriamycin of 3:1 for coenzyme Q10 (ubiquinone), 5:1 for coenzyme Q7, and 5:1 for coenzyme Q4. Prevention of inhibition was observed in the decreasing order of coenz...

While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a n...

CoQ10 was discovered by Dr. Frederick L. Crane at the University of Wisconsin in the late 1950s during his research on the biochemistry of the mitochondrial electron transport chain, also known as the respiratory chain. The pure substance isolated from beef heart mitochondria was sent to Dr. Karl Folkers at the pharmaceutical company Merck for identification and elucidation of its structure. It...

Single fiber recordings were made from auditory nerve fibers of the American bullfrog (Rana catesbeiana). As temperature was raised: (1) Best frequencies of fibers from the amphibian papilla (N = 15) increased. Below 600 Hz best frequency changes up to 0.06 oct/degrees C were found; above 600 Hz changes were less than 0.03 oct/degrees C. In the basilar papilla (N = 4) no significant increase of...

Purpose: The solubility of coenzyme Q10 (CoQ10) in water is extremely low, resulting in a low oral bioavailability. In this study, we attempted to improve the low dissolution and bioavailability of CoQ10, by means of the complexation with natural α-, βand γ-cyclodextrins (CyDs) and 2-hydroxypropyl-β-CyD (HP-β-CyD). Methods: The complexation of CoQ10 with CyDs was studied by the solubility metho...