When I qualified in medicine in Belfast in 1929 I had already formed the intention of pursuing my career overseas. I came of a medical family of which five members (my father, his three brothers and a sister) were all in general practice in Belfast so that I had an opportunity, if I wished, of joining an established practice. I had, however, lived through years of civil commotion in my student ...

While there is growing understanding of visual selective attention in children, some aspects such as selection in the presence of distractors are not well understood. Adult studies suggest that when presented with a visual search task, an enhanced negativity is seen beginning around 200 ms (the N2pc) that reflects selection of a target item among distractors. However, it is not known if similar...

Nonlinearity is ubiquitous in physical phenomena. Fluid and plasma mechanics, gas dynamics, elasticity, relativity, chemical reactions, combustion, ecology, biomechanics, and many, many other phenomena are all governed by inherently nonlinear equations. (The one notable exception is quantum mechanics, which is a fundamentally linear theory. Recent attempts at grand unification of all fundamenta...

Human papillomaviruses (HPV) are the main etiological factor for cervical carcinoma. HPV-16 is the most prevalent high-risk HPV-genotype found in HPV-associated cancers. We studied the effect of HPV-16 E7 oncoprotein on cadherin-mediated cell adhesion. The expression of E7 strongly suppressed the cadherin-mediated cell adhesion in the rat fibroblast cell line 3Y1. This suppression was associate...

Background: End-stage renal disease (ESRD) patients have poor health-related quality of life (HRQOL) comparing to general population and comparable HRQOL to patients with other major chronic diseases. Poor HRQOL is associated with shorter survival. There is a limited threshold to which dialysis dose and parameters management can improve HRQOL in ESRD patients. Numerous studies have sought to fi...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 207 No. 4 549–567 www.jcb.org/cgi/doi/10.1083/jcb.201404001 JCB 549 *Mohammed I. Ahmed and Majid Alam contributed equally to this paper. Correspondence to Natalia V. Botchkareva: [email protected] Abbreviations used in this paper: BIO, 6-bromoindirubin-3-oxime; Dox, doxycycline; DTG, double transgenic K14-rtTA/miR-214-TRE; E...

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