cml in breif cml is characterized by the proliferation of large numbers of immature wbc in the blood and bone marrow. in most of the patients , it is a clonal disorder in which all cell lines, express the philadelphia chromosome)q/22 translocation(it accounts for 20 of all leukemias and most cases occur over 25 yrs of age. the disease usually begins insidiously,but symptoms referable to anemia or organomegaly occur early)splenomegaly is present in over 90 of patients(. a tvpical cbc was illustrated in the previous pages. chemical abnormalities include elevated serum uricacid , vit b12 and loh.the leukocyte alkaline phosphatase is low.the bone marrow is hyper cellular. ii: diagnosis. the diagnosis is based on the tvpical abnormal laboratory finding and the presencc of ph-chromosome. the d.dx includes the other myeloproliferative disorders and leukemoid reactions. iii: treat ment treatment is predicated on an understanding of the natural history of the disorder.the rate of progression of cml varies from pt topt. thus there s no way to accurately guage the prognosis for a given pt.treatment depends on stage of dis,chronic phase of accelerated phase.