ارزیابی مقاومت آنتی بیوتیکی استافیلوکوکوس اورئوس های جدا شده از بینی پرسنل در بیمارستان آموزشی- درمانی دانشگاه شاهد (1382-1381)

Background and purpose:Staphylococcus aureaus(staph. Âureaus) is a common cause of nosocomial infections, and in many cases, the sources of infections are hospital Staff who one nasal carriers of the germ Determination of antibiotic resistance patterns of isolated strains are essential for treatment of nosicomial infections. Âs antibiotic resistance pattern can be used as a guideline in selection of proper antibiotic, resistance pattern of 87 species of Staph. aures isolated from nose of the two teaching hospitals staff was determined against 14 different antibiotics. Materials and methods: Disc diffusion method was used fordefection of Staph aureus resistance pattern to antibiotic. Âlso agar dilution method was performed for determination of minimal inhibitory concentration (MÏÇ) for oxacillin. Results: Most of the samples (90.8%) were resistant to penicillin. No resistance to vancomycin and rifampin was observed. The rate of resistance to the other antibiotics were as follows: Âmoxyclare 33.3%, tetracycline 19.8, Ërythromycin cephalexin and ciprefeloxazine 3.5% clindamycin 2.8% gentamycin 2.3% cephalethin 1.2%. MTÇ for different straing of the bacteria was different ( 256 migrogram/Liter). Ïn total 11.8% of the staph. aureas were resistant to methicillin. Çonclusion: This study showed that, some of the hospital staff are carriers of sometimes antibiotic pesistout staph. aureau,. Çontinnuous study on the transmission patern of antibiotic resistant in hospital staff carriores is necessary in order to control the nosocmial infection. Ïn addition, using the resistance pattern, proper antibiotics can be selected for carriors treatment.