Comparison of Serum CA-125 Level in Ruptured and Unruptured Tubal Pregnancies in Yazd/Iran during 2001-2006

Background & Aims: This study aimed to determine if serial measurement of serum CA-125 level could be used as a useful test in the differential diagnosis of intact and ruptured tubal pregnancies. Methods: In a single-blind prospective controlled clinical study, 59 women with tubal pregnancy of 6– 12 weeks (26 women with ruptured tubal pregnancy, 33 women with intact tubal pregnancy and 59women with normal intrauterine pregnancy of the same gestational age as control group) were studied prospectively. Serum CA-125 levels were measured in all women and compared among three groups. Results: Demographic features (age, gestational age, parity and educational level) were not significantly different in three groups. CA-125 level in ruptured tubal pregnancy group was significantly higher than that in control group (P = 0.04). Both these two groups had higher levels of CA-125 comparing to the intact tubal pregnancy group (P = 0.001, P = 0.006, respectively). Conclusion: In intact tubal pregnancies managed with medical treatment, serial measurements of CA-125 could be a supplementary test for an early diagnosis of tubal rupture.